Interleukin-18 and interleukin-1β:: Two cytokine substrates for ICE (Caspase-1)

被引：411
作者：
Fantuzzi, G [1 ]
Dinarello, CA [1 ]
机构：
[1] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Infect Dis, Denver, CO 80262 USA
来源：
JOURNAL OF CLINICAL IMMUNOLOGY | 1999年 / 19卷 / 01期
关键词：
cytokines; processing enzymes; proteinase-3; interleukin-18; interleukin-1; caspases;
D O I：
10.1023/A:1020506300324
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-nducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternative cleavage enzyms. The topic of this review also concerns the biology of IL-18. The regulation of IL-18 production, the IL-18 receptor complex, and the biological effects of this novel cytokine are described.
引用
收藏
页码：1 / 11
页数：11
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