Pancreatic cancer stem cell biology and its therapeutic implications

被引：25

作者：

Bednar, Filip ^{[1
,2
]}

Simeone, Diane M. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Med Ctr, Dept Physiol TC 2210B, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Med Ctr, Dept Mol & Integrat Physiol TC 2210B, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF GASTROENTEROLOGY | 2011年 / 46卷 / 12期

关键词：

Pancreatic cancer; Cancer stem cells; Therapeutic resistance; Epithelial-mesenchymal transition; ACUTE MYELOID-LEUKEMIA; DUCTAL ADENOCARCINOMA; SIGNALING PATHWAY; TUMOR-GROWTH; MOUSE MODEL; IDENTIFICATION; HEDGEHOG; ACTIVATION; WNT; EQUILIBRIUM;

D O I：

10.1007/s00535-011-0494-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic cancer remains one of the most difficult malignancies to treat. Significant developments in our understanding of pancreatic cancer biology have occurred over the past decade. One of the key advances has been the formulation of the cancer stem cell model of tumor growth and subsequent experimental proof of pancreatic cancer stem cell existence. Cancer stem cells contribute to pancreatic tumor growth and progression and are at least partially responsible for the relative resistance of the tumor to systemic chemotherapy and radiation. Significant questions remain about how the mutational profile of the tumor, the tumor microenvironment, and normal pancreatic developmental pathways contribute to pancreatic cancer stem cell biology. Answers to these questions will likely yield new therapeutic approaches for this deadly disease.

引用

页码：1345 / 1352

页数：8

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