Synthesis and Antimicrobial Evaluation of Some 1-Phenyl-3-(5-phenyl-1H-imidazol-1-yl)thiourea Derivatives

A series of 17 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea derivatives (3a-6d) was synthesized and tested for their antibacterial and antifungal activity along with their minimum inhibitory concentration values against various pathogenic and non-pathogenic microorganisms. Some of the synthesized compounds displayed excellent activity against various bacteria and fungi. Most of the synthesized compounds were found to be remarkably active against Gram-positive bacteria such as Staphylococcus aureus (NCIM 2122) and Bacillus subtilis (MTCC 121) and Gram-negative bacterial strains such as Escherichia coli (MTCC 118), Salmonella typhi (NCIM 2501), Klebsiella pneumoniae (MTCC 3384), and Pseudomonas aeruginosa (NCIL 2306). Among which compounds 3a, 3b, 4a, 4b, 5a, 5b, 6a, and 6b showed the maximum activity against above bacteria as antibacterial but less effective than the standard ciprofloxacin and norfloxacin. All compounds (3a-68) showed moderate activity against fungal strains such as Candida albicans (MTCC 227) and Aspergillus niger (NCIM 1056). [GRAPHICS] .