NRF2 Mediates Epigenetic Changes in DNA and Chromatin Structure to Regulate γ-Globin Gene Expression in a Human βYAC Transgenic Mouse Model

被引：0
|
作者：
Zhu, Xingguo [1 ,2 ]
Ward, Alexander H. [1 ]
Xi, Caixia [2 ]
Pace, Betty S. [1 ,2 ,3 ]
机构：
[1] Augusta Univ, Dept Pediat, Augusta, GA USA
[2] Augusta Univ, Georgia Canc Ctr, Augusta, GA USA
[3] Augusta Univ, Dept Biochem & Mol Biol, Augusta, GA USA
来源：
BLOOD | 2018年 / 132卷
关键词：
D O I：
10.1182/blood-2018-99-116438
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1053
引用
收藏
页数：2
相关论文
共 22 条
  • [1] NRF2 mediates γ-globin gene regulation through epigenetic modifications in a β-YAC transgenic mouse model
    Zhu, Xingguo
    Xi, Caixia
    Ward, Alexander
    Takezaki, Mayuko
    Shi, Huidong
    Peterson, Kenneth R.
    Pace, Betty S.
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2020, 245 (15) : 1308 - 1318
  • [2] Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic mice
    Rupon, JW
    Wang, SZ
    Gaensler, K
    Lloyd, J
    Ginder, GD
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (17) : 6617 - 6622
  • [3] NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors
    Zhu, Xingguo
    Li, Biaoru
    Pace, Betty S.
    HAEMATOLOGICA, 2017, 102 (08) : E285 - E288
  • [4] Transgenic Expression of Human Nrf2 Evokes Reductive Stress Transcriptome in Mouse Hearts
    Rajkumar, Abinayaa
    Sunny, Sini
    Dalley, Brian
    Sundaram, Sandhya
    Ramamurthy, Muralidharan T.
    Milash, Brett
    Kalaiselvi, Periandavan
    Namakkal-Soorappan, Rajasekaran
    FREE RADICAL BIOLOGY AND MEDICINE, 2020, 159 : S96 - S96
  • [5] Changes in Nrf2 Expression in the Spinal Cord in Mouse Model of Experimental Autoimmune Encephalomyelitis
    Nam, Sung Min
    Lee, Jun Ho
    Chang, Byung-Joon
    Lee, Jong-Hwan
    Tae, Hyun-Jin
    PAKISTAN VETERINARY JOURNAL, 2019, 39 (01) : 7 - 12
  • [6] Sulforaphane-induced epigenetic regulation of Nrf2 expression by DNA methyltransferase in human Caco-2 cells
    Zhou, Jia-Wei
    Wang, Min
    Sun, Nuan-Xin
    Qing, Ying
    Yin, Teng-Fei
    Li, Cui
    Wu, Dong
    ONCOLOGY LETTERS, 2019, 18 (03) : 2639 - 2647
  • [7] Gene expression changes in a transgenic mouse model overexpressing human wildtype and mutant torsinA
    Grundmann, Kathrin
    Huebener, Jeannette
    Haebig, Karina
    Reischmann, Bettina
    Poths, Sven
    Hauser, Till-Karsten
    Magg, Janine
    Riess, Olaf
    Bonin, Michael
    Nguyen, Huu Phuc
    PROTEOMICS CLINICAL APPLICATIONS, 2008, 2 (05) : 720 - 736
  • [8] The Transcription Factor Nrf2 Mediates the Effects of Antrodia camphorata Extract on Neuropathological Changes in a Mouse Model of Parkinson's Disease
    Lanza, Marika
    Cucinotta, Laura
    Casili, Giovanna
    Filippone, Alessia
    Basilotta, Rossella
    Capra, Anna Paola
    Campolo, Michela
    Paterniti, Irene
    Cuzzocrea, Salvatore
    Esposito, Emanuela
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (11)
  • [9] Gene Expression, Morphological and Behavioral Changes Associated with a Mouse Model of Mild Repetitive TBI and Treatment with Activators of Nrf2 and PPARγ Transcription Factors
    Ratliff, W. A.
    Qubty, D.
    Smith, C. M.
    Michaels, T.
    Pick, C. G.
    Citron, B. A.
    CELL TRANSPLANTATION, 2019, 28 (04) : 482 - 482
  • [10] Dynamic Changes of Gene Expression During the Development of Mouse Esophageal Epithelium and the Role of NRF2/Keap1 Pathway
    Chen, Hao
    Li, Jianying
    Li, Haiyan
    Hu, Yuhui
    Tevebaugh, Whitney
    Que, Jianwen
    Chen, Xiaoxin L.
    GASTROENTEROLOGY, 2012, 142 (05) : S492 - S493
123