Isolation and structure elucidation of new PKCα inhibitors from Pinus flexilis

被引：29
作者：
Lee, KK
Bahler, BD
Hofmann, GA
Mattern, MR
Johnson, RK
Kingston, DGI [1 ]
机构：
[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
[2] SmithKline Beecham Pharmaceut, Dept Biomol Discovery, King Of Prussia, PA 19406 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 11期
关键词：
D O I：
10.1021/np9801460
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioassay-guided fractionation of the CH2Cl2-MeOH extract of Pinus flexilis using an assay for protein kinase C (PKC) inhibitory activity led to the isolation of the two new bioactive diarylheptanoids (3R)-1,7-bis(3,4-dihydroxyphenyl)-3-(beta-D-glucopyranosyl)heptan-3-ol (1) and its aglycon (3R)-1,7-bis(3,4-dihydroxyphenyl)heptan-3-ol (2), together with the three known bioactive compounds, hirsutenone (3), oregonin (4), and hirsutanonol (5). The IC50 values of compounds 1-5 in the PKC assay were 1.4, 1.6, 1.4, 8.6, and 4.6 mu g/mL, respectively.
引用
收藏
页码：1407 / 1409
页数：3
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