P19:: a female and tissue specifically expressed gene in Schistosoma mansoni, regulated by pairing with the male

被引：13
作者：
Michel, A [1 ]
Knobloch, J [1 ]
Kunz, W [1 ]
机构：
[1] Inst Genet, D-40225 Dusseldorf, Germany
来源：
PARASITOLOGY | 2003年 / 127卷
关键词：
Schistosoma mansoni; egg-shell; male-female interaction; female-specific gene expression; pairing-dependent gene expression; FASCIOLA-HEPATICA; PROTEIN; LOCALIZATION; SEQUENCE; IDENTIFICATION; CLONING; CDNA;
D O I：
10.1017/S0031182003004244
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
A female-specific sequence was isolated from a cDNA library of Schistosoma mansoni and further characterized . Expression of the corresponding gene (p19) depends on pairing with a male. In situ hybridization and immunohistology experiments revealed exclusive expression of the gene in the cells of the vitellarium, suggesting a function in egg formation. In addition, experimental evidence for cross-linking of the protein under oxidative conditions supports the assumption that the p19 gene may code for an egg-shell precursor protein.
引用
收藏
页码：519 / 524
页数：6
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