Clinical Significance of Factor XIII Activity and Monocyte-Derived Microparticles in Cancer Patients

被引：7
作者：
Sawai, Yusuke [1 ]
Yamanaka, Yuta [1 ]
Nomura, Shosaku [1 ]
机构：
[1] Kansai Med Univ, Dept Internal Med 1, 2-3-1 Shin Machi, Hirakata, Osaka 5731191, Japan
来源：
VASCULAR HEALTH AND RISK MANAGEMENT | 2020年 / 16卷
基金：
日本学术振兴会;
关键词：
factor XIII activity; cancer; thrombosis; endothelial cell; monocyte-derived microparticle; MDMP; MEAN PLATELET VOLUME; TISSUE-FACTOR; COAGULATION-FACTOR; VENOUS THROMBOEMBOLISM; IN-VIVO; RISK; LUNG; THROMBOSIS; RECOMMENDATIONS; DEFICIENCY;
D O I：
10.2147/VHRM.S240500
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Background: The aim was to evaluate factor XIII activity (FXIIIa) and monocyte-derived microparticles (MDMPs) in cancer patients. Methods: In total, 138 cancer patients (31 malignant lymphomas, 39 multiple myelomas, and 68 lung cancers) were analyzed. We measured various biomarkers including FXIIIa and MDMPs. Results: The values of endothelial activation markers, monocyte chemoattractant peptide (MCP)-1, soluble (s)CD14, and MDMPs were higher in cancer patients than in noncancerous controls. MCP-1, sCD14, and MDMPs were significantly correlated with FXIIIa in multivariate analysis in cancer patients. In addition, MCP-1, sCD14, and MDMP levels were significantly increased in the high FXIIIa group of patients. Finally, the survival rate of the high FXIIIa group was significantly poor in the Kaplan-Meier analysis. Conclusion: These results suggest that abnormal levels of FXIIIa and MDMPs may offer promise as poor prognostic factors in cancer patients.
引用
收藏
页码：103 / 110
页数：8
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