GALNT14: An Emerging Marker Capable of Predicting Therapeutic Outcomes in Multiple Cancers

被引：33
作者：
Lin, Wey-Ran [1 ,2 ,3 ]
Yeh, Chau-Ting [1 ,2 ,3 ]
机构：
[1] Linkou Chang Gung Mem Hosp, Dept Gastroenterol & Hepatol, Taoyuan 333, Taiwan
[2] Linkou Chang Gung Mem Hosp, Liver Res Ctr, Taoyuan 333, Taiwan
[3] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 04期
关键词：
polypeptide N-acetylgalactosaminyltransferase; single nucleotide polymorphism; biomarker; cancer; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; O-GLYCOSYLATION; ADJUVANT CHEMOTHERAPY; POOR-PROGNOSIS; OVARIAN-CANCER; GENOTYPE; OXALIPLATIN; METASTASIS; PROMOTES; SURVIVAL;
D O I：
10.3390/ijms21041491
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Members of the polypeptide N-acetylgalactosaminyltransferase (GALNT) family function as the initiating enzymes that catalyze mucin-type O-glycosylation of proteins, and their dysregulated expression can alter cancer cell behaviors such as de novo occurrence, proliferation, migration, metastasis, and drug resistance. Recent studies have demonstrated that one of the family's members, GALNT14, is aberrantly expressed in multiple cancers and involved in a variety of biological functions. Moreover, the single nucleotide polymorphisms (SNPs) of GALNT14-rs9679162 have been shown to predict therapeutic outcomes in patients with hepatocellular carcinoma as well as several other different types of gastrointestinal cancer. This review summarizes the structural features of GANLT14, its functional roles, and the predictive values of GALNT14 genotypes and enzyme levels in multiple cancers receiving distinct anticancer therapies.
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页数：12
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