A short synthesis of argatroban: A potent selective thrombin inhibitor

被引：23

作者：

Cossy, J ^{[1
]}

Belotti, D ^{[1
]}

机构：

[1] ESPCI, CNRS, Chim Organ Lab, F-75231 Paris 05, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)00351-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Argatroban was synthesized in seven steps from 4-methylpiperidine. The condensation of (+/-)-trans-benzyl 4-methyl-pipecolic acid ester with N-alpha-Boc-N-omega-nitro-L-arginine led to two diastereomers that were separated. One of them is the precursor of argatroban. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1989 / 1992

页数：4