In Vivo Noninvasive Measurement of Young's Modulus of Elasticity in Human Eyes: A Feasibility Study

被引:44
作者
Sit, Arthur J. [1 ]
Lin, Shuai-Chun [1 ]
Kazemi, Arash [1 ]
McLaren, Jay W. [1 ]
Pruet, Christopher M. [1 ]
Zhang, Xiaoming [2 ,3 ]
机构
[1] Mayo Clin, Dept Ophthalmol, 200 1st St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA
[3] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA
关键词
ocular biomechanics; Young's modulus; elastography; ultrasound; corneal biomechanics; CENTRAL CORNEAL THICKNESS; OPEN-ANGLE GLAUCOMA; INTRAOCULAR-PRESSURE; BIOMECHANICAL PROPERTIES; RISK-FACTOR; BRILLOUIN MICROSCOPY; WAVE SPEED; HYSTERESIS; PROGRESSION; VISCOSITY;
D O I
10.1097/IJG.0000000000000774
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: Abnormal ocular biomechanical properties may be important for understanding the risk of glaucoma. However, there are no clinical methods for measuring standard material properties in patients. In this feasibility study we demonstrated proof-of-principle for a novel method, ultrasound surface wave elastography (USWE), to determine the in vivo Young's modulus of elasticity of corneas in normal human eyes. Methods: In total, 20 eyes of 10 healthy subjects (mean age, 51.4 +/- 7.2; +/- SD; range, 43 to 64 y) were studied. A spherical-tipped probe (3-mm diameter) was placed on closed eyelids and generated a gentle harmonic vibration at 100 Hz for 0.1 second. Wave speed propagation in the cornea was measured by USWE, and Young's modulus was calculated from the wave speed. Associations between Young's modulus and intraocular pressure (IOP), age, central corneal thickness, and axial length were explored by the Pearson correlation. Statistical significance was determined by using generalized estimating equation models to account for possible correlation between fellow eyes. Results: Mean IOP was 12.8 +/- 2.7mmHg. Mean wave speed in the cornea was 1.82 +/- 0.10 m/s. Young's modulus of elasticity was 696 +/- 113 kPa and was correlated with IOP (r= 0.57; P= 0.004), but none of the other variables (P> 0.1). Conclusions: USWE is a novel noninvasive technique for measuring ocular biomechanical properties. Corneal Young's modulus in normal eyes is associated with IOP, consistent with measurements in cadaver eyes. Further work is needed to determine elasticity in other ocular tissues, particularly the sclera, and if elasticity is altered in glaucoma patients.
引用
收藏
页码:967 / 973
页数:7
相关论文
共 41 条
[1]   Corneal Hysteresis and Visual Field Asymmetry in Open Angle Glaucoma [J].
Anand, Aashish ;
De Moraes, Carlos Gustavo V. ;
Teng, Christopher C. ;
Tello, Celso ;
Liebmann, Jeffrey M. ;
Ritch, Robert .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (12) :6514-6518
[2]  
Asrani S, 2000, J GLAUCOMA, V9, P134
[3]   Adjusting Intraocular Pressure for Central Corneal Thickness Does Not Improve Prediction Models for Primary Open-Angle Glaucoma [J].
Brandt, James D. ;
Gordon, Mae O. ;
Gao, Feng ;
Beiser, Julia A. ;
Miller, J. Phillip ;
Kass, Michael A. .
OPHTHALMOLOGY, 2012, 119 (03) :437-442
[4]   Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS) [J].
Brandt, JD ;
Beiser, JA ;
Kass, MA ;
Gordon, MO .
OPHTHALMOLOGY, 2001, 108 (10) :1779-1788
[5]  
Buzard K A, 1992, Refract Corneal Surg, V8, P127
[6]   Intraocular pressure fluctuation - A risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study [J].
Caprioli, Joseph ;
Coleman, Anne L. .
OPHTHALMOLOGY, 2008, 115 (07) :1123-1129
[7]   Shearwave Dispersion Ultrasound Vibrometry (SDUV) for Measuring Tissue Elasticity and Viscosity [J].
Chen, Shigao ;
Urban, Matthew W. ;
Pislaru, Cristina ;
Kinnick, Randall ;
Zheng, Yi ;
Yao, Aiping ;
Greenleaf, James F. .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2009, 56 (01) :55-62
[8]  
Cicchetti DV., 1994, PSYCHOL ASSESSMENTS, V6, P284, DOI [10.1037/1040-3590.6.4.284, DOI 10.1037/1040-3590.6.4.284]
[9]   Anterior and posterior corneal stroma elasticity assessed using nanoindentation [J].
Dias, Janice M. ;
Ziebarth, Noel M. .
EXPERIMENTAL EYE RESEARCH, 2013, 115 :41-46
[10]   Optic nerve head biomechanics in aging and disease [J].
Downs, J. Crawford .
EXPERIMENTAL EYE RESEARCH, 2015, 133 :19-29