Assessment of oil polarity: Comparison of evaluation methods

被引：38

作者：

El-Mahrab-Roberta, M. ^{[1
]}

Rosilio, V. ^{[1
]}

Bolzinger, M. -A. ^{[2
,3
]}

Chaminade, P. ^{[4
]}

Grossiord, J. -L. ^{[1
]}

机构：

[1] Univ Paris Sud, CNRS, UMR 8612, F-92296 Chatenay Malabry, France

[2] Univ Lyon 1, Lab Dermopharm & Cosmetol, ISPB, F-69003 Lyon, France

[3] CNRS, UMR 5007, Lab Automat & Genie Procedes, F-69622 Villeurbanne, France

[4] Univ Paris Sud, CNRS, EA 4041 Grp Chim Analytique, F-92296 Chatenay Malabry, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2008年 / 348卷 / 1-2期

关键词：

multiple emulsions; molecular transport; oil polarity; interfacial tension; HPLC;

D O I：

10.1016/j.ijpharm.2007.07.027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In multiple emulsion systems, oily or aqueous transfers may occur between the dispersed droplets through the continuous phase. These transfers are controlled by both the surfactant system (micellar transport), and the partial solubility of one phase in another (molecular transport). The latter could be anticipated from the knowledge of oil polarity, if this information could easily be obtained. In this work, the relative polarity of eight oils used for various purposes has been evaluated from the comparison of their dielectric requirement for solubilization, their interfacial tension and chromatographic analysis. The results showed the complementarities of HPLC analysis and interfacial tension measurements and their superiority over the solubilization method for classifying oils as a function of their polarity. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：89 / 94

页数：6

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