Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus

被引：3
作者：
Sotak, S. [1 ,2 ]
Felsoci, M.
Lazurova, I
Habalova, V
机构：
[1] PJ Safarikiensis Univ, Dept Internal Med 1, L Pasteur Univ Hosp, Trieda SNP 1, SK-04011 Kosice, Slovakia
[2] PJ Safarikiensis Univ, Sch Med, Trieda SNP 1, SK-04011 Kosice, Slovakia
来源：
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2018年 / 119卷 / 12期
关键词：
diabetes mellitus 2; deiodinase II; polymorphism Thr92Ala; THR92ALA POLYMORPHISM; INSULIN-RESISTANCE; ASSOCIATION; VARIANT; GENE;
D O I：
10.4149/BLL_2018_144
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 2 diabetes mellitus (T2DM) remains one of the most challenging global epidemics of the twenty-first century. It is estimated that more than 350 million people worldwide are affected by this metabolic disorder. It has many risk factors. Several studies presume that type II iodothyronine deiodinase polymorphism Thr92Ala (DII-Thr92-Ala, rs225014) is yet another risk factor. The aim of the study was to assess the impact of this polymorphism on parameters of glycid metabolism. Our group consisted of 200 subjects (74 males and 126 females) at average age of 63.85 +/- 18.98 without prediabetes, diabetes mellitus or any thyropathy. Blood tests were performed to evaluate glucose metabolism parameters as well as DII-Thr92Ala polymorphism. Our study confirmed the relationship between Ala homozygotes and glycosylated haemoglobin (HbA(1c)) serum levels.
引用
收藏
页码：790 / 792
页数：3
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