Foxg1 mRNA overexpression in neonatal rats following hypoxic brain injury

被引：0

作者：

Li, Luquan ^{[1
]}

Zheng, Yi ^{[1
]}

Mo, Guoliang ^{[1
]}

Li, Fang ^{[1
]}

Yu, Jialin ^{[1
]}

机构：

[1] Chongqing Med Univ, Childrens Hosp, Neonatal Diag & Treatment Ctr, Chongqing 400014, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 01期

关键词：

Foxg1; mRNA; hypoxia injury; neonatal rats; cerebral cortex; CAJAL-RETZIUS CELLS; SUBVENTRICULAR ZONE; GENE-EXPRESSION; CEREBRAL-CORTEX; FACTOR-I; NEURONS; GROWTH; PROLIFERATION; NEUROGENESIS; HIPPOCAMPUS;

D O I：

10.3969/j.issn.1673-5374.2011.01.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Forkhead box G1 (Foxg1) is expressed during the embryonic stage and in postnatal brain regions sensitive to hypoxia/ischemia injury, such as the hippocampus and cerebral cortex. To date, very little is known about Foxg1 expression changes in the brain following hypoxia injury (HI). The present study measured Foxg1 mRNA expression using reverse-transcription polymerase chain reaction on days 3, 7, 14, 28, and 56 following HI to determine self-restorative features in the injured brain. In addition, mRNA expression of other related layer markers, such as Reelin, ROR beta, Foxp1, Foxp2, ER81, and Otx-1, was detected following HI. Results revealed significantly decreased Foxg1 mRNA expression at 3 days after HI, which significantly increased by 56 days. Reelin and Foxp2 mRNA expression were upregulated until 56 days after HI, but Foxp1 and ER81 mRNA expression decreased from day 14 to 56 following HI. In addition, Otx-1 and ROR beta mRNA expression decreased from day 3 to 28 after HI. These findings revealed Fxog1 mRNA overexpression and varying degrees of restoration in the neonatal rat brain following HI.

引用

页码：41 / 46

页数：6

共 38 条

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