TRAIL is involved in human osteoclast apoptosis

被引：10

作者：

Brunetti, Giacomina ^{[1
]}

Oranger, Angela ^{[1
]}

Mori, Giorgio ^{[2
]}

Tamma, Roberto ^{[1
]}

Di Benedetto, Adriana ^{[1
]}

Pignataro, Paolo ^{[1
]}

Grassi, Felice R. ^{[3
]}

Zallone, Alberta ^{[1
]}

Grano, Maria ^{[1
]}

Colucci, Silvia ^{[1
]}

机构：

[1] Univ Bari, Sch Med, Dept Human Anat & Histol, I-70124 Bari, Italy

[2] Univ Foggia, Dept Biomed Sci, Foggia, Italy

[3] Univ Bari, Dept Oral Sci, Bari, Italy

来源：

SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING | 2007年 / 1116卷

关键词：

TRAIL; TRAIL receptors; osteoclasts; apoptosis;

D O I：

10.1196/annals.1402.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Control of osteoclast (OC) apoptosis has been recognized as a critical regulatory factor in bone remodeling. TRAIL, a member of the TNF superfamily, induces apoptosis in neoplastic and normal cells. However, few data are available on the effects of TRAIL on bone cells, thus in the present study we investigated TRAIL role on the apoptosis of human mature OCs. We show that TRAIL treatment causes reduced cell viability, loss of nuclei integrity, and derangement of the actin microfilament in OCs. We also demonstrated that the death receptor DR5, upregulated by TRAIL, could be the mediator of TRAIL-induced OC apoptosis.

引用

页码：316 / 322

页数：7

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