A History of Bone Marrow Transplantation

被引：23
作者：
de la Morena, M. Teresa [1 ]
Gatti, Richard A. [2 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Div Allergy & Immunol, Dept Pediat & Internal Med, Dallas, TX 75390 USA
[2] Univ Calif Los Angeles, Sch Med, Macdonald Res Labs, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2011年 / 25卷 / 01期
关键词：
Bone marrow transplantation; History; Primary immunodeficiency diseases; STEM-CELL TRANSPLANTATION; SEVERE COMBINED IMMUNODEFICIENCY; CHRONIC GRANULOMATOUS-DISEASE; WISKOTT-ALDRICH-SYNDROME; VERSUS-HOST-DISEASE; CORD-BLOOD TRANSPLANTATION; LYMPHOPENIC IMMUNOLOGICAL DEFICIENCY; TERM IMMUNE RECONSTITUTION; HISTOCOMPATIBILITY GENES; ALLOGENEIC MARROW;
D O I：
10.1016/j.hoc.2010.11.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.
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页码：1 / +
页数：16
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