Ligand-controlled stereodivergent 1,3-dipolar cycloaddition of azomethine ylides with 3-methyl-4-nitro-5-styrylisoxazoles

被引：56

作者：

Liu, Kang ^{[1
]}

Xiong, Yong ^{[1
]}

Wang, Zuo-Fei ^{[1
]}

Tao, Hai-Yan ^{[1
]}

Wang, Chun-Jiang ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[2] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 230012, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 60期

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTORS; ASYMMETRIC 3+2 CYCLOADDITION; HIGHLY EFFICIENT; ENANTIOSELECTIVE ADDITION; 1,6-MICHAEL ADDITION; BINDING-AFFINITY; FACILE ACCESS; CONSTRUCTION; EPIBOXIDINE; ANALOGS;

D O I：

10.1039/c6cc03169b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unprecedented Ag(I)-catalyzed ligand-controlled stereodivergent 1,3-dipolar cycloaddition of azomethine ylides with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford heterocycles bearing both methylisoxazole and pyrrolidine moieties. The endo- and exo-cycloadducts were obtained in good yields with excellent stereoselectivities, assisted by Bu-t-Phosferrox and phosphoramidite as chiral ligands, respectively.

引用

页码：9458 / 9461

页数：4

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