Structure and mechanism of bacterial tripartite efflux pumps

被引：45

作者：

Neuberger, Arthur ^{[1
]}

Du, Dijun ^{[1
]}

Luisi, Ben E. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Tennis Court Rd, Cambridge CB2 1GA, England

来源：

RESEARCH IN MICROBIOLOGY | 2018年 / 169卷 / 7-8期

基金：

英国惠康基金;

关键词：

Multi-drug efflux pumps; Membrane proteins; Antibiotic resistance; Tripartite assemblies; GRAM-NEGATIVE BACTERIA; ENTERICA SEROVAR TYPHIMURIUM; ESCHERICHIA-COLI HEMOLYSIN; TYPE-1 SECRETION SYSTEM; MEMBRANE-FUSION PROTEIN; 2-COMPONENT SIGNAL-TRANSDUCTION; MULTIPLE ANTIBIOTIC-RESISTANCE; TRANSPORTER P-GLYCOPROTEIN; MULTIDRUG ABC TRANSPORTER; DRUG-BINDING POCKET;

D O I：

10.1016/j.resmic.2018.05.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic membrane fusion protein. These tripartite machineries span both membranes and the periplasmic space, and they extrude from the bacterium chemically diverse toxic substrates. In this chapter, we summarise current understanding of the structural architecture, functionality, and regulation of tripartite multi-drug efflux assemblies. (C) 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：401 / 413

页数：13

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