Recommendations of the Brazilian Society of Rheumatology for the use of JAK inhibitors in the management of rheumatoid arthritis

被引：4

作者：

Bonfiglioli, Karina Rossi ^{[1
]}

da Mota, Licia Maria Henrique ^{[2
]}

de Medeiros Ribeiro, Ana Cristina ^{[1
]}

Kakehasi, Adriana Maria ^{[3
]}

Laurindo, Ieda Maria Magalhaes ^{[4
]}

Giorgi, Rina Dalva Neubarth ^{[5
]}

Duarte, Angela Luzia Branco Pinto ^{[6
]}

Reis, Ana Paula Monteiro Gomides ^{[2
]}

de Souza, Mariana Peixoto Guimaraes Ubirajara e Silva ^{[7
]}

Brenol, Claiton Viegas ^{[8
]}

da Rocha Castelar Pinheiro, Geraldo ^{[9
]}

de Albuquerque, Cleandro Pires ^{[2
]}

de Moura Castro, Charlles Heldan ^{[10
]}

Pinto, Gustavo Luiz Behrens ^{[11
]}

Verztman, Jose Fernando ^{[12
]}

Muniz, Luciana Feitosa ^{[13
]}

Bertolo, Manoel Barros ^{[14
]}

da Costa Pinto, Maria Raquel ^{[3
]}

Louzada Junior, Paulo ^{[15
]}

Cruz, Vitor Alves ^{[16
]}

Pereira, Ivanio Alves ^{[17
]}

de Freitas, Max Vitor Carioca ^{[18
]}

Cruz, Boris Afonso ^{[19
]}

Paiva, Eduardo ^{[20
]}

Monticielo, Odirlei ^{[8
]}

Provenza, Jose Roberto ^{[21
]}

Xavier, Ricardo Machado ^{[8
]}

机构：

[1] Univ Sao Paulo HC FMUSP, Fac Med, Disciplina Reumatol Hosp Clin, Av Dr Arnaldo,455-3 Andar Reumatol, BR-01246903 Sao Paulo, SP, Brazil

[2] Univ Brasilia HUB UnB, Serv Reumatol Hosp, Brasilia, DF, Brazil

[3] Univ Fed Minas Gerais UFMG, Serv Reumatol, Belo Horizonte, MG, Brazil

[4] Univ Nove Julho UNINOVE, Disciplina Reumatol, Sao Paulo, Brazil

[5] Hosp Servidor Publ Estadual Sao Paulo HSPE IAMSPE, Serv Reumatol, Sao Paulo, Brazil

[6] Univ Fed Pernambuco UFPE, Recife, PE, Brazil

[7] Santa Casa Belo Horizonte MG, Belo Horizonte, MG, Brazil

[8] Univ Fed Rio Grande Sul HCPA UFRGS, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

[9] Univ Estado Rio De Janeiro UERJ, Rio De Janeiro, Brazil

[10] Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil

[11] Univ Fed Bahia UFBA, Salvador, BA, Brazil

[12] Hosp Fed Servidores Estado RJ, Rio De Janeiro, Brazil

[13] Hosp Reg Sobradinho DF, Brasilia, DF, Brazil

[14] Univ Estadual Campinas, Fac Ciencias Med, Disciplina Reumatol, Campinas, Brazil

[15] Univ Sao Paulo USP RP, Fac Med Ribeirao Preto, Disciplina Reumatol, Ribeirao Preto, Brazil

[16] Univ Fed Goias, Fac Med, Disciplina Reumatol, Goiania, Go, Brazil

[17] Univ Fed Santa Catarina UFSC, Serv Reumatol, Hosp Univ, Florianopolis, SC, Brazil

[18] Univ Fortaleza UNIFOR, Fortaleza, Ceara, Brazil

[19] Pulsus Belo Horizonte MG, Belo Horizonte, MG, Brazil

[20] Univ Fed Parana UFPR, Disciplina Reumatol, Curitiba, Parana, Brazil

[21] Univ Catolica Campinas, PUC Campinas, Disciplina Reumatol Pontificia, Campinas, Brazil

来源：

ADVANCES IN RHEUMATOLOGY | 2021年 / 61卷 / 01期

关键词：

COST-EFFECTIVENESS ANALYSIS; INADEQUATE RESPONSE; TOFACITINIB CP-690,550; DOUBLE-BLIND; FILGOTINIB GLPG0634/GS-6034; BACKGROUND METHOTREXATE; JAPANESE PATIENTS; AMERICAN-COLLEGE; ZOSTER VACCINE; HERPES-ZOSTER;

D O I：

10.1186/s42358-021-00228-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis (RA) is a chronic and autoimmune systemic inflammatory disease that can cause irreversible joint deformities, with increased morbidity and mortality and a significant impact on the quality of life of the affected individual. The main objective of RA treatment is to achieve sustained clinical remission or low disease activity. However, up to 40% of patients do not respond to available treatments, including bDMARDs. New therapeutic targets for RA are emerging, such as Janus kinases (JAKs). These are essential for intracellular signaling (via JAK-STAT) in response to many cytokines involved in RA immunopathogenesis. JAK inhibitors (JAKi) have established themselves as a highly effective treatment, gaining increasing space in the therapeutic arsenal for the treatment of RA. The current recommendations aim to present a review of the main aspects related to the efficacy and safety of JAKis in RA patients, and to update the recommendations and treatment algorithm proposed by the Brazilian Society of Rheumatology in 2017.

引用

页数：13

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