Thermo-responsive poly(N-isopropylacrylamide)-hyaluronic acid nano-hydrogel and its multiple applications

被引：28
作者：
Xu, Lifeng [1 ]
Zhong, Shuangling [2 ]
Gao, Yan [1 ,3 ]
Cui, Xuejun [1 ,3 ]
机构：
[1] Jilin Univ, Coll Chem, 2699 Qianjin St, Changchun 130012, Peoples R China
[2] Jilin Agr Univ, Coll Resources & Environm, 2888 Xincheng St, Changchun 130118, Peoples R China
[3] Jilin Univ, Weihai Inst Bion, Weihai 264400, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2022年 / 194卷
关键词：
Aggregation-induced emission; Temperature stimulus; Targeting cancer; AGGREGATION-INDUCED EMISSION; CLUSTERING-TRIGGERED EMISSION; HYALURONIC-ACID; TEMPERATURE; EFFICIENT; POLYMER; SENSORS; PH;
D O I：
10.1016/j.ijbiomac.2021.11.133
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is a huge challenge to construct a nanoprobe that can convert temperature stimulation into monochromatic signal with "turn-on" function. Here, a drug delivery system of berberine (BBR)-loaded hyaluronic acid (HA)modified-L-cysteine (Cys) grafted (N-isopropylacrylamide) (PNIPAM) was structured. HA-Cys-PN/BBR does not need to introduce other substances or external stimuli, by adjusting the temperature of this system, the fluorescence responsive intensity and reversible reciprocating control of the nanohydrogel with aggregation induced emission (AIE) performance can be realized. In addition, CD44-HA interaction can be used as targeting the delivery of cancer cells, thus, there is a great interest in development of targeting and imaging agents as payloads for tumor tissue therapy. Therefore, it can provide a side of the development with self-released drugs in the therapy of cancers or bacterial infections. Thus, HA-Cys-PN/BBR as AIE reversible nanogel has longer-term applications in biomedical applications.
引用
收藏
页码：811 / 818
页数：8
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