Chemotherapy and cancer stem cells

被引:130
作者
Rich, Jeremy N. [1 ]
Bao, Shideng
机构
[1] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Dept Med, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Dept Surg, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA
[4] Univ Colorado Denver, Dept Radiat Oncol, Aurora, CO 80045 USA
[5] Univ Colorado Denver, Dept Neurosurg, Aurora, CO 80045 USA
[6] Hlth Sci Ctr, Aurora, CO 80045 USA
关键词
D O I
10.1016/j.stem.2007.09.011
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Cancer stem cells are subsets of tumor cells defined through the capacity to initiate tumors and have been linked to therapeutic resistance. In this issue of Cell Stem Cell, Todaro, et al. (2007) demonstrate that targeting tumor IL-4 sensitizes colon cancer stem cells to chemotherapy.
引用
收藏
页码:353 / 355
页数:3
相关论文
共 10 条
[1]   Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].
Bao, Shideng ;
Wu, Qiulian ;
McLendon, Roger E. ;
Hao, Yueling ;
Shi, Qing ;
Hjelmeland, Anita B. ;
Dewhirst, Mark W. ;
Bigner, Darell D. ;
Rich, Jeremy N. .
NATURE, 2006, 444 (7120) :756-760
[2]   Phenotypic characterization of human colorectal cancer stem cells [J].
Dalerba, Piero ;
Dylla, Scott J. ;
Park, In-Kyung ;
Liu, Rui ;
Wang, Xinhao ;
Cho, Robert W. ;
Hoey, Timothy ;
Gurney, Austin ;
Huang, Emina H. ;
Simeone, Diane M. ;
Shelton, Andrew A. ;
Parmiani, Giorgio ;
Castelli, Chiara ;
Clarke, Michael F. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (24) :10158-10163
[3]   Cancer stem cells: Models and concepts [J].
Dalerba, Piero ;
Cho, Robert W. ;
Clarke, Michael F. .
ANNUAL REVIEW OF MEDICINE, 2007, 58 :267-284
[4]   A human colon cancer cell capable of initiating tumour growth in immunodeficient mice [J].
O'Brien, Catherine A. ;
Pollett, Aaron ;
Gallinger, Steven ;
Dick, John E. .
NATURE, 2007, 445 (7123) :106-110
[5]   The response of CD24-/low/CD44+ breast cancer-initiating cells to radiation [J].
Phillips, Tiffany M. ;
McBride, William H. ;
Pajonk, Frank .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (24) :1777-1785
[6]   Stem cells, cancer, and cancer stem cells [J].
Reya, T ;
Morrison, SJ ;
Clarke, MF ;
Weissman, IL .
NATURE, 2001, 414 (6859) :105-111
[7]   Identification and expansion of human colon-cancer-initiating cells [J].
Ricci-Vitiani, Lucia ;
Lombardi, Dario G. ;
Pilozzi, Emanuela ;
Biffoni, Mauro ;
Todaro, Matilde ;
Peschle, Cesare ;
De Maria, Ruggero .
NATURE, 2007, 445 (7123) :111-115
[8]   Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4 [J].
Todaro, Matilde ;
Alea, Mileidys Perez ;
Di Stefano, Anna B. ;
Cammareri, Patrizia ;
Vermeulen, Louis ;
Lovino, Flora ;
Tripodo, Claudio ;
Russo, Antonio ;
Gulotta, Gaspare ;
Medema, Jan Paul ;
Stassi, Giorgio .
CELL STEM CELL, 2007, 1 (04) :389-402
[9]   WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells [J].
Woodward, Wendy A. ;
Chen, Mercy S. ;
Behbod, Fariba ;
Alfaro, Maria P. ;
Buchholz, Thomas A. ;
Rosen, Jeffrey M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (02) :618-623
[10]   A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia [J].
Wulf, GG ;
Wang, RY ;
Kuehnle, I ;
Weidner, D ;
Marini, F ;
Brenner, MK ;
Andreeff, M ;
Goodell, MA .
BLOOD, 2001, 98 (04) :1166-1173