Cacolides: Sesterterpene Butenolides from a Southern Australian Marine Sponge, Cacospongia sp.

被引：13

作者：

Khushi, Shamsunnahar ^{[1
]}

Nahar, Laizuman ^{[1
]}

Salim, Angela A. ^{[1
]}

Capon, Robert J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

MARINE DRUGS | 2018年 / 16卷 / 11期

关键词：

Cacospongia sp; sesterterpene butenolides; dereplication; GNPS; sesterterpene tetronic acids; TETRONIC ACID; VARIABILIN; LUFFARIELLOLIDE; DERIVATIVES; SECRETION;

D O I：

10.3390/md16110456

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical analysis of a marine sponge, Cacospongia sp. (CMB-03404), obtained during deep sea commercial fishing activities off the southern coast of Australia, yielded an unprecedented family of sesterterpene -methyl--hydroxybutenolides, cacolides A-L (1-12), together with biosynthetically related norsesterterpene carboxylic acids, cacolic acids A-C (13-15). Structures were assigned on the basis of detailed spectroscopic analysis with comparisons to known natural products and biosynthetic considerations. In addition to revealing new chemical diversity, this study provided a valuable platform for comparing and contrasting the capabilities of the traditional dereplication technologies of HPLC-DAD, HPLC-MS and NMR, with those of the emerging HPLC-MS/MS approach known as global natural products social molecular networking (GNPS), as applied to marine sponge sesterterpene tetronic acids.

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页数：17

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