CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer

被引：49

作者：

Coventry, BJ

Morton, J

机构：

[1] Univ Adelaide, Royal Adelaide Hosp, Dept Surg, Breast Endocrine & Surg Oncol Unit, Adelaide, SA 5000, Australia

[2] Univ Adelaide, Royal Adelaide Hosp, Dept Surg, Tumour Immunol Lab, Adelaide, SA 5000, Australia

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 89卷 / 03期

关键词：

CD1a; dendritic cells; breast cancer; survival;

D O I：

10.1038/sj.bjc.6601114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Infiltrating CD1a(+) dendritic cells (DCs) have been associated with increased survival in a number of human cancers. This study investigated DC infiltration within breast cancers and the association with survival. Classical established prognostic factors, of tumour size, lymph node status, histological grade, lympho-vascular invasion, the KI-67 (MIB-1) fraction and the Nottingham Prognostic Index (NPI) were also compared. A total of 48 breast cancer patients were followed from the time of surgery and CD1a density analysis for 5 years or until death. Our data set validated previous studies, which show a relationship between survival and the NPI (P<0.001), tumour size (P<0.01) and lymph node status (P<0.05). Although more patients were alive at the 5-year time point in the group with higher CD1a DC density than the lower CD1a DC group, this failed to reach statistical significance at the P = 0.05 level. Analysis at 10 years postsurgery is required to investigate the association further.

引用

页码：533 / 538

页数：6

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