A retrospective study of autologous stem cell mobilization by G-CSF in combination with chemotherapy in patients with multiple myeloma and lymphoma

被引：22
作者：
Zheng, Gaofeng [1 ,2 ]
He, Jingsong [1 ,2 ]
Cai, Zhen [1 ,2 ]
He, Donghua [1 ,2 ]
Luo, Yi [1 ,2 ]
Shi, Jimin [1 ,2 ]
Wei, Guoqing [1 ,2 ]
Sun, Jie [1 ,2 ]
Zheng, Weiyan [1 ,2 ]
机构：
[1] Zhejiang Univ, Bone Marrow Transplantat Ctr, Affiliated Hosp 1, 79 Qingchun Rd, Hangzhou 310001, Zhejiang, Peoples R China
[2] First Hosp Zhejiang Prov, 79 Qingchun Rd, Hangzhou 310001, Zhejiang, Peoples R China
来源：
ONCOLOGY LETTERS | 2020年 / 19卷 / 01期
基金：
中国国家自然科学基金;
关键词：
hematopoietic stem cells; mobilization; separation; collection; influencing factors; multiple myeloma; lymphoma; COLONY-STIMULATING FACTOR; PREDICTIVE FACTORS; TRANSPLANTATION; EFFICIENCY; PLERIXAFOR; IMPACT; REMOBILIZATION; COLLECTION; THERAPY; FAILURE;
D O I：
10.3892/ol.2019.11177
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Factors affecting peripheral blood hematopoietic stem cell (PBSC) mobilization and collection were investigated in patients with multiple myeloma (MM) and lymphoma who were undergoing chemotherapy. Clinical data from 128 patients, including 53 MM and 75 malignant lymphoma (7 Hodgkin's lymphoma and 68 non-Hodgkin's lymphoma) cases were retrospectively analyzed. Autologous PBSCs were mobilized using granulocyte-colony stimulating factor (G-CSF) during chemotherapy, and collected using a continuous flow cell separation instrument. The yields of CD34+ cells per kilogram of patient body weight <2.0x10(6)/kg, >2.0x10(6)/kg or >5.0x10(6)/kg were defined as a failure, a success or ideal mobilization, respectively. In MM and lymphoma patients, the success rates of CD34+ cell acquisition were 73.6 (39/53) and 58.7% (44/75), the ideal rates were 43.4 (23/53) and 30.7% (23/75), and the failure rates were 26.4 (14/53) and 41.3% (31/75), respectively. Univariate and multivariate statistical analysis revealed that negative factors for PBSC mobilization in patients with MM were lenalidomide treatment, multiple chemotherapies, incomplete disease remission and low-level blood hemoglobin; in patients with lymphoma, the negative factors were the histological disease type, incomplete disease remission, being beyond the first-line of previous chemotherapy, multiple chemotherapies, chemotherapy with the HyperCVAD-B mobilization scheme, high-dose MTX/Ara-c (methotrexate/cytarabine) treatment, prolonged administration of G-CSF and low-hematocrit levels. In the present study, different factors influencing PBSC mobilization and collection in MM and lymphoma cases were identified. PBSC mobilization yielded sufficient CD34+ cell counts both in MM and lymphoma patients; however, the failure rates were relatively high.
引用
收藏
页码：1051 / 1059
页数：9
相关论文
共 34 条
[21]   Factors impacting stem cell mobilization failure rate and efficiency in multiple myeloma in the era of novel therapies: experience at Memorial Sloan Kettering Cancer Center [J].
Pozotrigo, M. ;
Adel, N. ;
Landau, H. ;
Lesokhin, A. ;
Lendvai, N. ;
Chung, D. J. ;
Chimento, D. ;
Riedel, E. ;
Chen, X. ;
Reich, L. ;
Comenzo, R. ;
Giralt, S. ;
Hassoun, H. .
BONE MARROW TRANSPLANTATION, 2013, 48 (08) :1033-1039
[22]   Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation [J].
Pusic, Iskra ;
Jiang, Shi Yuan ;
Landua, Scott ;
Uy, Geoffrey L. ;
Rettig, Michael P. ;
Cashen, Amanda F. ;
Westervelt, Peter ;
Vij, Ravi ;
Abboud, Camille N. ;
Stockerl-Goldstein, Keith E. ;
Sempek, Diane S. ;
Smith, Angela L. ;
DiPersio, John F. .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (09) :1045-1056
[23]   Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management [J].
Rajkumar, S. Vincent .
AMERICAN JOURNAL OF HEMATOLOGY, 2014, 89 (10) :999-1009
[24]   Stem cell mobilization in HIV seropositive patients with lymphoma [J].
Re, Alessandro ;
Cattaneo, Chiara ;
Skert, Cristina ;
Balsalobre, Pascual ;
Michieli, Mariagrazia ;
Bower, Mark ;
Ferreri, Andres J. M. ;
Hentrich, Marcus ;
Ribera, Jose M. ;
Allione, Bernardino ;
Schommers, Philipp ;
Montoto, Silvia ;
Almici, Camillo ;
Ferremi, Pierino ;
Mazzucato, Mario ;
Gattillo, Salvatore ;
Casari, Salvatore ;
Spina, Michele ;
Diez-Martin, Jose L. ;
Tirelli, Umberto ;
Rossi, Giuseppe .
HAEMATOLOGICA, 2013, 98 (11) :1762-1768
[25]   PBSC mobilization in lymphoma patients: analysis of risk factors for collection failure and development of a predictive score based on the kinetics of circulating CD34+cells and WBC after chemotherapy and G-CSF mobilization [J].
Rossi, Giuseppe ;
Skert, Cristina ;
Morello, Enrico ;
Almici, Camillo ;
Arcaini, Luca ;
Basilico, Claudia ;
Cavalli, Lara ;
Botto, Barbara ;
Castelli, Andrea ;
Pica, Gianmatteo ;
Ripamonti, Francesco ;
Salvi, Flavia ;
Carella, Angelo M. ;
Gaidano, Gianluca ;
Levis, Alessandro ;
Nosari, Annamaria ;
Russo, Domenico ;
Vitolo, Umberto .
HEMATOLOGICAL ONCOLOGY, 2015, 33 (03) :125-132
[26]   Plerixafor and granulocyte colony-stimulating factor for first-line steady-state autologous peripheral blood stem cell mobilization in lymphoma and multiple myeloma: results of the prospective PREDICT trial [J].
Russell, Nigel ;
Douglas, Kenny ;
Ho, Anthony D. ;
Mohty, Mohamad ;
Carlson, Kristina ;
Ossenkoppele, G. J. ;
Milone, Giuseppe ;
Ortiz Pareja, Macarena ;
Shaheen, Daniel ;
Willemsen, Arnold ;
Whitaker, Nicky ;
Chabannon, Christian .
HAEMATOLOGICA, 2013, 98 (02) :172-178
[27]   MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1 [J].
Salvucci, Ombretta ;
Jiang, Kan ;
Gasperini, Paola ;
Maric, Dragan ;
Zhu, Jinfang ;
Sakakibara, Shuhei ;
Espigol-Frigole, Georgina ;
Wang, Shushang ;
Tosato, Giovanna .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (06) :818-826
[28]   Predictive factors for poor peripheral blood stem cell mobilization and peak CD34+ cell count to guide pre-emptive or immediate rescue mobilization [J].
Sancho, Juan-Manuel ;
Morgades, Mireia ;
Grifols, Joan-Ramon ;
Junca, Jordi ;
Guardia, Ramon ;
Vives, Susana ;
Ferra, Christelle ;
Batlle, Monsterrat ;
Ester, Anna ;
Gallardo, David ;
Milla, Fuensanta ;
Feliu, Evarist ;
Ribera, Josep-Maria .
CYTOTHERAPY, 2012, 14 (07) :823-829
[29]   Plerixafor and G-CSF for autologous stem cell mobilization in patients with NHL, Hodgkin's lymphoma and multiple myeloma: results from the expanded access program [J].
Shaughnessy, P. ;
Uberti, J. ;
Devine, S. ;
Maziarz, R. T. ;
Vose, J. ;
Micallef, I. ;
Jacobsen, E. ;
McCarty, J. ;
Stiff, P. ;
Artz, A. ;
Ball, E. D. ;
Berryman, R. ;
Dugan, M. ;
Joyce, R. ;
Hsu, F. J. ;
Johns, D. ;
McSweeney, P. .
BONE MARROW TRANSPLANTATION, 2013, 48 (06) :777-781
[30]   Characterization and outcome of "hard to mobilize" lymphoma patients undergoing autologous stem cell transplantation [J].
Sugrue, MW ;
Williams, K ;
Pollock, BH ;
Khan, S ;
Peracha, S ;
Wingard, JR ;
Moreb, JS .
LEUKEMIA & LYMPHOMA, 2000, 39 (5-6) :509-519
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