Ultra-structural morphology analysis of human cranial bone marrow mesenchymal stromal cells during neural differentiation

被引：1
|
作者：
Ma, Yuyuan [1 ]
Zhang, Qulin [2 ]
Yang, Kaichuang [1 ]
Ma, Jie [3 ]
Pan, Ruolang [4 ,5 ]
Lu, Gang [1 ]
机构：
[1] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Dept Neurosurg, Peoples Hosp, Hangzhou 310014, Peoples R China
[2] Nanxun Peoples Hosp, Dept Neurosurg, Huzhou 313009, Peoples R China
[3] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Dept Pathol, Peoples Hosp, Hangzhou 310014, Peoples R China
[4] Key Lab Cell Based Drug & Appl Technol Dev Zhejia, Hangzhou 311121, Peoples R China
[5] Inst Cell Based Drug Dev Zhejiang Prov, S Evans Biosci, Hangzhou 311121, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2021年 / 763卷
关键词：
Mesenchymal stromal cells; Neural differentiation; Morphology; Ultrastructural differences; Microvesicles; STEM-CELLS; SPINAL-CORD; BRAIN; RAT; TRANSPLANTATION; EXOSOMES; THERAPY; BENEFIT; INJURY;
D O I：
10.1016/j.neulet.2021.136179
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neural differentiation of mesenchymal stromal cells has been widely studied. However, a comparative charac-terization of ultrastructural changes during neural differentiation has not been performed. In this study, we conducted scanning electron microscopy and transmission electron microscopy analysis to show the morpho-logical changes in mesenchymal stromal cells upon induction of neural differentiation. In addition, transmission electron microscopy results demonstrated ultrastructural differences between human cranial bone marrow mesenchymal stromal cells and iliac crest bone marrow mesenchymal stromal cells. We propose that enriched microvesicles in cranial bone marrow mesenchymal stromal cells may be responsible for the increased efficiency of neural differentiation.
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页数：6
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