magnetic particle imaging (MPI);
complex susceptibility (AC susceptibility);
point spread function (PSF);
full width at half maximum (FWHM);
relaxation time;
superparamagnetic iron oxide nanoparticles (SPIONs);
ARBITRARY-WAVE-FORM;
RESOLUTION;
OPTIMIZATION;
SENSITIVITY;
RELAXOMETER;
D O I:
10.1088/1361-6501/ac72fc
中图分类号:
T [工业技术];
学科分类号:
08 ;
摘要:
Spatial resolution is a key metric for characterizing magnetic particle imaging (MPI), and magnetic relaxation is a critical factor affecting the spatial resolution. This study investigates the point spread functions (PSFs) of MPI and analyzes the potential of breaking through the spatial resolution limit, which equals the full width at half maximum (FWHM) of the Langevin function derivative. In this work, different PSFs of MPI were built based on the magnitude and real and imaginary parts of complex susceptibility. The imaging performance was evaluated using the FWHM and a self-defined convergence parameter. The results show that image reconstruction can achieve a narrower PSF based on the imaginary part of complex susceptibility, and the heavy-tailed distribution of the derivative of the Langevin curve can be optimized. This suggests that there is scope to improve the spatial resolution and image contrast of MPI.
机构:
Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USAHarvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA
Jia, Shu
Vaughan, Joshua C.
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机构:
Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USAHarvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA
Vaughan, Joshua C.
Zhuang, Xiaowei
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h-index: 0
机构:
Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
Harvard Univ, Dept Phys, Cambridge, MA 02138 USAHarvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA