Autophagy is a catabolic process conserved among all eukaryotes essential for the cellular and organismal homeostasis. One of the principal roles of this pathway is to maintain an accurate balance between synthesis, degradation and subsequent recycling of cellular components. Under certain conditions, however, cells are also able to modulate autophagy and specifically remove a number of structures that are potentially harmful. Aberrant protein aggregates, damaged organelles or pathogens can be selectively incorporated into large double-membrane vesicles called autophagosomes to be delivered into lysosomes for destruction. This ability to eliminate specific structures is exploited by the cells in several physiological processes as well as in multiple pathological situations, making autophagy a precious multitask cellular degradative pathway. In this review, we will first examine what is known about the basic mechanisms of autophagy and then discuss in a second part the nature of the cargoes that are selectively sequestered into autophagosomes, what provides the specificity and the possible implications of selective types of autophagy in human pathologies.
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Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Bernales, Sebastian
McDonald, Kent L.
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机构:Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
McDonald, Kent L.
Walter, Peter
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机构:Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
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Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA
Bernales, Sebastian
Papa, Feroz R.
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机构:Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA
Papa, Feroz R.
Walter, Peter
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机构:Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA
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Canc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, EnglandCanc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, England
Chan, Edmond Y. W.
Kir, Serkan
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Canc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, EnglandCanc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, England
Kir, Serkan
Tooze, Sharon A.
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Canc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, EnglandCanc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, England
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Hara, Taichi
Nakamura, Kenji
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Nakamura, Kenji
Matsui, Makoto
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Matsui, Makoto
Yamamoto, Akitsugu
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Yamamoto, Akitsugu
Nakahara, Yohko
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Nakahara, Yohko
Suzuki-Migishima, Rika
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Suzuki-Migishima, Rika
Yokoyama, Minesuke
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Yokoyama, Minesuke
Mishima, Kenji
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Mishima, Kenji
Saito, Ichiro
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Saito, Ichiro
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Okano, Hideyuki
Mizushima, Noboru
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Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, JapanTokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
机构:Univ Michigan, Life Sci Ctr, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Huang, Ju
Klionsky, Daniel J.
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Univ Michigan, Life Sci Ctr, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Ctr, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
Bernales, Sebastian
McDonald, Kent L.
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h-index: 0
机构:Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
McDonald, Kent L.
Walter, Peter
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机构:Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
机构:
Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USAUniv Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA
Bernales, Sebastian
Papa, Feroz R.
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h-index: 0
机构:Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA
Papa, Feroz R.
Walter, Peter
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h-index: 0
机构:Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem & Biophys, San Francisco, CA 94143 USA
机构:
Canc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, EnglandCanc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, England
Chan, Edmond Y. W.
Kir, Serkan
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, EnglandCanc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, England
Kir, Serkan
Tooze, Sharon A.
论文数: 0引用数: 0
h-index: 0
机构:
Canc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, EnglandCanc Res UK London Res Inst, Secretory Pathways Lab, London WC2A 3PX, England
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Hara, Taichi
Nakamura, Kenji
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Nakamura, Kenji
Matsui, Makoto
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Matsui, Makoto
Yamamoto, Akitsugu
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h-index: 0
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Yamamoto, Akitsugu
Nakahara, Yohko
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Nakahara, Yohko
Suzuki-Migishima, Rika
论文数: 0引用数: 0
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Suzuki-Migishima, Rika
Yokoyama, Minesuke
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Yokoyama, Minesuke
Mishima, Kenji
论文数: 0引用数: 0
h-index: 0
机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Mishima, Kenji
Saito, Ichiro
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机构:Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
Saito, Ichiro
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Okano, Hideyuki
Mizushima, Noboru
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, JapanTokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan
机构:Univ Michigan, Life Sci Ctr, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
Huang, Ju
Klionsky, Daniel J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Life Sci Ctr, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USAUniv Michigan, Life Sci Ctr, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA