Catalytic Asymmetric Darzens and Aza-Darzens Reactions for the Synthesis of Chiral Epoxides and Aziridines

被引：27

作者：

de los Santos, Jesus M. ^{[1
]}

Ochoa de Retana, Ana M. ^{[1
]}

Martinez de Marigorta, Edorta ^{[1
]}

Vicario, Javier ^{[1
]}

Palacios, Francisco ^{[1
]}

机构：

[1] Univ Pais Vasco UPV EHU, Dept Quim Organ 1, Fac Quim, Ctr Invest & Estudios Avanzados Lucio Lascaray, Paseo Univ 7, Vitoria 01006, Spain

来源：

CHEMCATCHEM | 2018年 / 10卷 / 22期

关键词：

aza-Darzens reaction; aziridines; Darzens reaction; epoxides; catalytic asymmetric synthesis; BOND-FORMING REACTIONS; PHASE-TRANSFER; ENANTIOSELECTIVE SYNTHESIS; AZACROWN ETHERS; D-GLUCOSE; EFFICIENT SYNTHESIS; CROWN CATALYSTS; GLYCIDIC AMIDES; GENERAL-METHOD; IMINES;

D O I：

10.1002/cctc.201801026

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This review presents an overview on the recent advances in the catalytic enantioselective Darzens and aza-Darzens reactions for the synthesis of enantiopure three-membered oxygen and nitrogen containing heterocycles. Since the synthesis of epoxides is the most widely explored, compared to their nitrogen counterparts, particularly true when asymmetric synthesis are considered, in the last decades several methodologies have appeared or improved and are now available for the preparation of aziridines in a highly stereo- and enantioselective manner. Catalytic asymmetric Darzens and aza-Darzens reaction constitute an important tool in modern organic chemistry, as there is an increased interest in bioactive natural products and pharmaceutical agents that contain these skeletons.

引用

页码：5092 / 5114

页数：23

共 118 条

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