Chemical probe of AHL modulators on quorum sensing in Gram-Negative Bacteria and as antiproliferative agents: A review

被引：32
作者：
Ampomah-Wireko, Maxwell [1 ,2 ,3 ,4 ]
Luo, Chunying [1 ,2 ,3 ,4 ]
Cao, Yaquan [1 ,2 ,3 ,4 ]
Wang, Huanhuan [1 ,2 ,3 ,4 ]
Nininahazwe, Lauraine [1 ,2 ,3 ,4 ]
Wu, Chunli [1 ,2 ,3 ,4 ]
机构：
[1] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
[2] Minist Educ, Key Lab Adv Drug Preparat Technol, Zhengzhou 450001, Peoples R China
[3] Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
[4] Zhengzhou Key Lab New Vet Drug Preparat Innovat, Zhengzhou 450001, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 226卷
基金：
国家重点研发计划;
关键词：
Quorum sensing; Quorum sensing inhibitors; Quorum sensing systems; Acyl homoserine lactone (AHL); Structure-activity relationship (SAR); ACYL-HOMOSERINE LACTONES; PSEUDOMONAS-AERUGINOSA; BIOLOGICAL EVALUATION; INHIBITORS; DESIGN; DERIVATIVES; LIBRARY; ANALOGS; ANTAGONISTS; REGULATOR;
D O I：
10.1016/j.ejmech.2021.113864
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pathogenic bacteria use an intercellular chemical communication system called quorum sensing (QS) to control the expression of cellular functions such as virulence factors, biofilm formation, toxin production, and antibiotic resistance in a manner that is highly dependent on population density. Hence, since the emergence of QS, there has been a great interest in exploiting the QS mechanism as a new drug target. Therefore, blocking the QS mechanism can be an effective strategy to control infection and solve the problem of drug resistance. So far, there is no clinically approved anti-QS drug that can disable the circuits of QS systems. This review discusses the quorum-sensing network systems and novel anti-QS inhibitors in some Gram-negative bacteria. (C) 2021 Elsevier Masson SAS. All rights reserved.
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页数：25
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