A new CERAD total score with equally weighted z-scores and additional executive and non-amnestic "CERAD-Plus" tests enhances cognitive diagnosis in patients with Parkinson's disease: Evidence from the LANDSCAPE study

被引：10

作者：

Lillig, Robert ^{[1
,2
]}

Ophey, Anja ^{[1
,2
]}

Schulz, Joerg B. ^{[3
,4
,5
]}

Reetz, Kathrin ^{[3
,4
,5
]}

Wojtala, Jennifer ^{[3
,4
,5
]}

Storch, Alexander ^{[6
,7
]}

Liepelt-Scarfone, Inga ^{[8
,9
,10
]}

Becker, Sara ^{[8
]}

Berg, Daniela ^{[8
,11
]}

Balzer-Geldsetzer, Monika ^{[12
]}

Kassubek, Jan ^{[13
]}

Hilker-Roggendorf, Ruediger ^{[14
]}

Witt, Karsten ^{[15
,16
]}

Mollenhauer, Brit ^{[17
]}

Trenkwalder, Claudia ^{[17
]}

Roeske, Sandra ^{[18
]}

Wittchen, Hans-Ullrich ^{[19
]}

Riedel, Oliver ^{[20
]}

Dodel, Richard ^{[21
,22
]}

Kalbe, Elke ^{[1
,2
]}

机构：

[1] Univ Cologne, Fac Med, D-50937 Cologne, Germany

[2] Univ Hosp Cologne, Dept Med Psychol Neuropsychol & Gender Studies, Ctr Neuropsychol Diagnost & Intervent CeNDI, D-50937 Cologne, Germany

[3] Rhein Westfal TH Aachen, Dept Neurol, Pauwelsstr 30, Aachen, Germany

[4] Forschungszentrum Julich, JARA BRAIN Inst Mol Neurosci & Neuroimaging, D-52074 Aachen, Germany

[5] Rhein Westfal TH Aachen, D-52074 Aachen, Germany

[6] Univ Rostock, Dept Neurol, Gehlsheimer Str 20, D-18147 Rostock, Germany

[7] German Ctr Neurodegenerat Dis DZNE Rostock, Gehlsheimer Str 20, D-18147 Rostock, Germany

[8] Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Otfried Muller Str 27, D-72076 Tubingen, Germany

[9] German Ctr Neurodegenerat Dis DZNE, Otfried Muller Str 23, D-2372076 Tubingen, Germany

[10] IB Hsch Gesundheit & Soziales, Paulinenstr 45, D-70178 Stuttgart, Germany

[11] Christian Albrechts Univ Kiel, Dept Neurol, Arnold Heller Str 3, D-324105 Kiel, Germany

[12] Ludwig Maximilians Univ Munchen, Ethikkommiss, Pettenkoferstr 8, D-80336 Munich, Germany

[13] Univ Ulm, Dept Neurol, Oberer Eselsberg 45, D-89081 Ulm, Germany

[14] Klinikum Vest, Dept Neurol, Dorstener Str 151, D-45657 Recklinghausen, Germany

[15] Carl von Ossietzky Univ Oldenburg, Dept Neurol, Carl von Ossietzky Str 9, D-26129 Oldenburg, Germany

[16] Carl von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Carl von Ossietzky Str 9, D-26129 Oldenburg, Germany

[17] Univ Med Ctr, Dept Neurosurg, Paracelsus Elena Klin, Klinikstr 16, D-34128 Kassel, Germany

[18] German Ctr Neurodegenerat Dis DZNE, Dept Clin Res, Sigmund Freud Str 27, D-53127 Bonn, Germany

[19] Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Dept Psychiat & Psychotherapy, Nussbaurnstr 7, D-80336 Munich, Germany

[20] Leibniz Inst Prevent Res & Epidemiol BIPS, Dept Clin Epidemiol, Achterstr 30, D-28359 Bremen, Germany

[21] Philipps Univ Marburg, Dept Neurol, Baldingerstr, D-35043 Marburg, Germany

[22] Univ Hosp Essen, Dept Geriatr Med, Germaniastr 1, D-45356 Essen, Germany

来源：

PARKINSONISM & RELATED DISORDERS | 2021年 / 90卷

关键词：

Parkinson's disease; Cognitive impairment; Neuropsychological assessment; Consortium to establish a registry for Alzheimer's disease (CERAD); NEUROPSYCHOLOGICAL ASSESSMENT BATTERY; ALZHEIMERS-DISEASE; DEMENTIA; IMPAIRMENT; ACCURACY;

D O I：

10.1016/j.parkreldis.2021.07.034

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is a renowned cognitive test battery, which has been extended in its German version to the CERAD-Plus including tests of executive functions and processing speed. The most commonly used total score (TS) is based on the restricted CERAD version and reflects the sum of selected raw-values (Chandler et al., 2005). The CERAD-Plus extensions might be of particular diagnostic utility for cognitive assessments in Parkinson's Disease (PD), as executive functions and processing speed belong to the most vulnerable domains in PD. Objective: The aim was to develop a CERAD-TS based on the extended CERAD-Plus' age-, gender-, and education-corrected z-scores and to evaluate its diagnostic accuracy compared to the established CERAD-Chandler-TS. Methods: Baseline data of n = 679 patients with PD (69% male, n = 277 PD without cognitive impairment, n = 307 PD-MCI, n = 95 PD-D) from the multicenter, prospective DEMPARK/LANDSCAPE study were analyzed. ROC-analyses were conducted for four different TS that were either based on the original CERAD or CERAD-Plus, on raw-values or z-scores, and equally-weighted or based on factor scores. AUC-comparisons were conducted to determine the best yet most parsimonious TS. Results: The newly designed CERAD-Plus-TS based on equally-weighted z-scores outperformed both the CERADChandler-TS and cognitive screening instruments when differentiating between individuals with PD of varying cognitive impairment (0.78 <= AUC <= 0.98). Conclusion: Results suggest a high relevance of non-amnestic subscales for the cognitive assessment in PD populations. The proposed CERAD-Plus-TS needs further validation. The extensions might offer diagnostic potential for non-PD populations as well.

引用

页码：90 / 97

页数：8

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