The clinical significance of the glucocorticoid receptors: Genetics and epigenetics

被引：25

作者：

Motavalli, Roza ^{[1
]}

Majidi, Taraneh ^{[1
]}

Pourlak, Tala ^{[2
]}

Abediazar, Sima ^{[1
]}

Shoja, Mohammadali M. ^{[3
]}

Vahed, Sepideh Zununi ^{[1
]}

Etemadi, Jalal ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Dept Pathol, Tabriz, Iran

[3] Ross Univ, Clin Acad Teaching & Learning, Sch Med, Miramar, FL USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2021年 / 213卷

关键词：

Glucocorticoid receptor; Steroid-resistance; Methylation; PITUITARY-ADRENAL AXIS; BODY-MASS INDEX; NR3C1; GENE; ER22/23EK POLYMORPHISM; N363S POLYMORPHISM; METABOLIC SYNDROME; BCLI POLYMORPHISM; EATING-DISORDERS; TURKISH PATIENTS; RISK-FACTORS;

D O I：

10.1016/j.jsbmb.2021.105952

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The impacts of glucocorticoids (GCs) are mainly mediated by a nuclear receptor (GR) existing in almost every tissue. The GR regulates a wide range of physiological functions, including inflammation, cell metabolism, and differentiation playing a major role in cellular responses to GCs and stress. Therefore, the dysregulation or disruption of GR can cause deficiencies in the adaptation to stress and the preservation of homeostasis. The number of GR polymorphisms associated with different diseases has been mounting per year. Tackling these clinical complications obliges a comprehensive understanding of the molecular network action of GCs at the level of the GR structure and its signaling pathways. Beyond genetic variation in the GR gene, epigenetic changes can enhance our understanding of causal factors involved in the development of diseases and identifying biomarkers. In this review, we highlight the relationships of GC receptor gene polymorphisms and epigenetics with different diseases.

引用

页数：13

共 159 条

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