β-fibrinogen gene-455G/A polymorphism and coronary heart disease incidence:: The Atherosclerosis Risk in Communities (ARIC) Study

被引：34

作者：

Folsom, AR

Aleksic, N

Ahn, C

Boerwinkle, E

Wu, KK

机构：

[1] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55454 USA

[2] Univ Texas, Sch Med, Clin Epidemiol Sect, Houston, TX USA

[3] Univ Texas, Houston Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA

[4] Univ Texas, Houston Hlth Sci Ctr, Inst Mol Med, Houston, TX USA

[5] Univ Texas, Sch Med, Div Hematol, Houston, TX USA

来源：

ANNALS OF EPIDEMIOLOGY | 2001年 / 11卷 / 03期

关键词：

coronary disease; fibrinogen; prospective study;

D O I：

10.1016/S1047-2797(00)00203-9

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

PURPOSE: The -455G/A (HaeIII) polymorphism of the beta -fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease. METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -445G/A status with a random sample of the cohort (n = 498). RESULTS: Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD. CONCLUSIONS: Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD. Ann Epidemiol 2001;11:166-170. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：166 / 170

页数：5

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