Daratumumab for Treatment of Antibody-Mediated Rejection after ABO-Incompatible Kidney Transplantation

被引：40

作者：

Spica, Davide ^{[1
]}

Junker, Till ^{[2
]}

Dickenmann, Michael ^{[1
]}

Schaub, Stefan ^{[1
,3
,4
]}

Steiger, Jurg ^{[1
,3
]}

Rufli, Tanja ^{[5
]}

Halter, Jorg ^{[2
]}

Hopfer, Helmut ^{[6
]}

Holbro, Andreas ^{[2
,5
]}

Hirt-Minkowski, Patricia ^{[1
]}

机构：

[1] Univ Hosp Basel, Transplantat Immunol & Nephrol, Basel, Switzerland

[2] Univ Hosp Basel, Dept Med, Div Hematol, Basel, Switzerland

[3] Univ Basel, Dept Biomed, Transplantat Immunol, Basel, Switzerland

[4] Univ Hosp Basel, Dept Lab Med, HLA Diagnost & Immunogenet, Basel, Switzerland

[5] Swiss Red Cross, Blood Transfus Serv, Basel, Switzerland

[6] Univ Hosp Basel, Inst Pathol, Basel, Switzerland

来源：

CASE REPORTS IN NEPHROLOGY AND DIALYSIS | 2019年 / 9卷 / 03期

关键词：

Antibody-mediated rejection; ABO-incompatible kidney transplantation; Anti-rejection therapy; Daratumumab; RENAL-ALLOGRAFT SURVIVAL; IMMUNOSUPPRESSION; MONOTHERAPY; BORTEZOMIB;

D O I：

10.1159/000503951

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report the effectiveness of daratumumab, a human IgG. monoclonal antibody targeting CD38 on plasma cells, for therapy-refractory antibody-mediated rejection (AMR) due to blood group antibodies in a 59-year-old man who received a living ABO-incompatible kidney transplantation. Standard treatment options for AMR due to blood group antibodies including immunoadsorption, lymphocyte depletion with anti-human T-lymphocyte globulins, intravenous methylprednisolone pulses and eculizumab limited tissue injury, however failed to sufficiently suppress blood group antibody production. After administration of daratumumab as a rescue therapy, blood group antibody titers decreased and remained at low levels without further immunoadsorption and allowed kidney graft function to recover. (C) 2019 The Author(s) Published by S. Karger AG, Basel.

引用

页码：149 / 157

页数：9

共 28 条

[1] Summary of FDA Antibody-Mediated Rejection Workshop [J].

Archdeacon, P. ;

Chan, M. ;

Neuland, C. ;

Velidedeoglu, E. ;

Meyer, J. ;

Tracy, L. ;

Cavaille-Coll, M. ;

Bala, S. ;

Hernandez, A. ;

Albrecht, R. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 (05) :896-906

[2] Daratumumab for Delayed Red-Cell Engraftment after Allogeneic Transplantation [J].

Chapuy, Claudia I. ;

Kaufman, Richard M. ;

Alyea, Edwin P. ;

Connors, Jean M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (19) :1846-1850

[3] Resolving the daratumumab interference with blood compatibility testing [J].

Chapuy, Claudia I. ;

Nicholson, Rachel T. ;

Aguad, Maria D. ;

Chapuy, Bjoern ;

Laubach, Jacob P. ;

Richardson, Paul G. ;

Doshi, Parul ;

Kaufman, Richard M. .

TRANSFUSION, 2015, 55 (06) :1545-1554

[4] Antibody-mediated organ-allograft rejection [J].

Colvin, RB ;

Smith, RN .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (10) :807-817

[5] An update on the role of daratumumab in the treatment of multiple myeloma [J].

Costello, Caitlin .

THERAPEUTIC ADVANCES IN HEMATOLOGY, 2017, 8 (01) :28-37

[6] Acute antibody-mediated rejection in kidney transplant recipients [J].

Davis, Scott ;

Cooper, James E. .

TRANSPLANTATION REVIEWS, 2017, 31 (01) :47-54

[7] ABO-Incompatible Kidney Transplant Outcomes A Meta-Analysis [J].

de Weerd, Annelies E. ;

Betjes, Michiel G. H. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2018, 13 (08) :1234-1243

[8] Antibody-Mediated Microcirculation Injury Is the Major Cause of Late Kidney Transplant Failure [J].

Einecke, G. ;

Sis, B. ;

Reeve, J. ;

Mengel, M. ;

Campbell, P. M. ;

Hidalgo, L. G. ;

Kaplan, B. ;

Halloran, P. F. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 (11) :2520-2531

[9] ABO-incompatible kidney transplantation [J].

Fehr, Thomas ;

Stussi, Georg .

CURRENT OPINION IN ORGAN TRANSPLANTATION, 2012, 17 (04) :376-385

[10] Evidence for Antibody-Mediated Injury as a Major Determinant of Late Kidney Allograft Failure [J].

Gaston, Robert S. ;

Cecka, J. Michael ;

Kasiske, Bert L. ;

Fieberg, Ann M. ;

Leduc, Robert ;

Cosio, Fernando C. ;

Gourishankar, Sita ;

Grande, Joseph ;

Halloran, Philip ;

Hunsicker, Lawrence ;

Mannon, Roslyn ;

Rush, David ;

Matas, Arthur J. .

TRANSPLANTATION, 2010, 90 (01) :68-74

← 1 2 3 →