Expression of Serotonin Transporter in Mice With Ethanol Physical Dependency

被引：11

作者：

Shibasaki, Masahiro ^{[1
]}

Inoue, Mariko ^{[2
]}

Kurokawa, Kazuhiro ^{[1
]}

Ogou, Satoru ^{[2
]}

Ohkuma, Seitaro ^{[1
,2
]}

机构：

[1] Kawasaki Med Sch, Dept Pharmacol, Kurashiki, Okayama 7010192, Japan

[2] Kawasaki Med Sch, Lab Anim Ctr, Kurashiki, Okayama 7010192, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 114卷 / 02期

关键词：

ethanol; physical dependence; serotonin transporter; DEPRESSION; AMYGDALA; BINDING;

D O I：

10.1254/jphs.10146SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

in the present study, we investigated whether ethanol physical dependence causes changes of serotonin transporter (SERT) expression in the brain. SERT expression increased in the cingulate cortex, nucleus accumbens, hippocampal CA1-CA3 layers, and mediodorsal nucleus of the thalamus and decreased in the basolateral nucleus of the amygdala. In addition, chronic ethanol treatment increased SERT mRNA in the dorsal raphe nucleus from which serotonergic neurons originate, although no SERT mRNA was detected in the regions where SERT protein increased. These findings suggest that alteration of SERT levels in the brain may be related to emotional changes observed in ethanol physical dependence.

引用

页码：234 / 237

页数：4

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