Expression of Serotonin Transporter in Mice With Ethanol Physical Dependency

被引：11
作者：
Shibasaki, Masahiro [1 ]
Inoue, Mariko [2 ]
Kurokawa, Kazuhiro [1 ]
Ogou, Satoru [2 ]
Ohkuma, Seitaro [1 ,2 ]
机构：
[1] Kawasaki Med Sch, Dept Pharmacol, Kurashiki, Okayama 7010192, Japan
[2] Kawasaki Med Sch, Lab Anim Ctr, Kurashiki, Okayama 7010192, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 114卷 / 02期
关键词：
ethanol; physical dependence; serotonin transporter; DEPRESSION; AMYGDALA; BINDING;
D O I：
10.1254/jphs.10146SC
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
in the present study, we investigated whether ethanol physical dependence causes changes of serotonin transporter (SERT) expression in the brain. SERT expression increased in the cingulate cortex, nucleus accumbens, hippocampal CA1-CA3 layers, and mediodorsal nucleus of the thalamus and decreased in the basolateral nucleus of the amygdala. In addition, chronic ethanol treatment increased SERT mRNA in the dorsal raphe nucleus from which serotonergic neurons originate, although no SERT mRNA was detected in the regions where SERT protein increased. These findings suggest that alteration of SERT levels in the brain may be related to emotional changes observed in ethanol physical dependence.
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收藏
页码：234 / 237
页数：4
相关论文
共 15 条
  • [1] BLAKELY RD, 1994, J EXP BIOL, V196, P263
  • [2] Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Cannon, Dara M.
    Ichise, Masanori
    Fromm, Stephen J.
    Nugent, Allison C.
    Rollis, Denise
    Gandhi, Shilpa K.
    Klaver, Jacqueline M.
    Charney, Dennis S.
    Manji, Husseini K.
    Drevets, Wayne C.
    [J]. BIOLOGICAL PSYCHIATRY, 2006, 60 (03) : 207 - 217
  • [3] Serotonergic Function, Two-Mode Models of Self-Regulation, and Vulnerability to Depression: What Depression Has in Common With Impulsive Aggression
    Carver, Charles S.
    Johnson, Sheri L.
    Joormann, Jutta
    [J]. PSYCHOLOGICAL BULLETIN, 2008, 134 (06) : 912 - 943
  • [4] Dysfunction in the neural circuitry of emotion regulation - A possible prelude to violence
    Davidson, RJ
    Putnam, KM
    Larson, CL
    [J]. SCIENCE, 2000, 289 (5479) : 591 - 594
  • [5] The amygdala: vigilance and emotion
    Davis, M
    Whalen, PJ
    [J]. MOLECULAR PSYCHIATRY, 2001, 6 (01) : 13 - 34
  • [6] GOLDSTEIN DB, 1972, J PHARMACOL EXP THER, V180, P203
  • [7] Genetics of emotional regulation: the role of the serotonin transporter in neural function
    Hariri, AR
    Holmes, A
    [J]. TRENDS IN COGNITIVE SCIENCES, 2006, 10 (04) : 182 - 191
  • [8] Redefining the serotonergic system by genetic lineage
    Jensen, Patricia
    Farago, Anna F.
    Awatramani, Rajeshwar B.
    Scott, Michael M.
    Deneris, Evan S.
    Dymecki, Susan M.
    [J]. NATURE NEUROSCIENCE, 2008, 11 (04) : 417 - 419
  • [9] Anxiety-like behaviors following chronic ethanol exposure
    Kliethermes, CL
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 28 (08) : 837 - 850
  • [10] SEROTONIN AND ALCOHOL INTAKE, ABUSE, AND DEPENDENCE - FINDINGS OF ANIMAL STUDIES
    LEMARQUAND, D
    PIHL, RO
    BENKELFAT, C
    [J]. BIOLOGICAL PSYCHIATRY, 1994, 36 (06) : 395 - 421
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