Cytotoxic pentacyclic triterpenoids from the rhizome of Astilbe chinensis

被引：50
|
作者：
Sun, HX
Zhang, JX
Ye, YP
Pan, YJ [1 ]
Shen, YA
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
[2] Zhejiang Univ, Coll Anim Sci, Hangzhou 310029, Peoples R China
[3] Key Lab Chem Nat Prod Guizhou Province, Guiyang 550000, Peoples R China
[4] Chinese Acad Sci, Guiyang 550000, Peoples R China
[5] Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou 310013, Peoples R China
[6] Acad Sinica, Kunming Inst Bot, Kunming 650204, Peoples R China
来源：
HELVETICA CHIMICA ACTA | 2003年 / 86卷 / 07期
关键词：
D O I：
10.1002/hlca.200390194
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Guided by in vitro antineoplastic tests, four cytotoxic pentacyclic triterpenoids, 3beta-hydroxyolean-12-en-27-oic acid (1), 3beta-hydroxyurs-12-en-27-oic acid (2), 3beta,6beta-dihydroxyolean-12-en-27-oic acid (3), and 3beta-acetoxyolean-12-en-27-oic acid (4) were isolated from the rhizome of Astilbe chinensis. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods including one-dimensional and two-dimensional NMR. These compounds showed cytotoxic activities against HO-8910, Hela and HL60 cell lines. In addition, beta-sitosterol palmitate, daucosterol, and beta-sitosterol have also been isolated.
引用
收藏
页码：2414 / 2423
页数：10
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