Nonpeptide inhibitors of the pp60c-src (Src) SH2 domain:: Discovery of a novel phosphotyrosine mimetic

被引：0

作者：

Kawahata, N ^{[1
]}

Yang, M ^{[1
]}

Luke, G ^{[1
]}

Shakespeare, W ^{[1
]}

Sundaramoorthi, R ^{[1
]}

Wang, YH ^{[1
]}

Johnson, D ^{[1
]}

Merry, T ^{[1
]}

Violette, S ^{[1
]}

Guan, W ^{[1
]}

Bartlett, C ^{[1
]}

Smith, J ^{[1
]}

Hatada, M ^{[1
]}

Lu, XD ^{[1
]}

Eyermann, C ^{[1
]}

Bohacek, R ^{[1
]}

Dalgarno, D ^{[1
]}

Sawyer, T ^{[1
]}

机构：

[1] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

PEPTIDES FOR THE NEW MILLENNIUM | 2000年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：561 / 562

页数：2

共 7 条

[1] Enantioselective synthesis of nonphosphorus-containing phosphotyrosyl mimetics and their use in the preparation of tyrosine phosphatase inhibitory peptides [J].

Burke, TR ;

Yao, ZJ ;

Zhao, H ;

Milne, GWA ;

Wu, L ;

Zhang, ZY ;

Voigt, JH .

TETRAHEDRON, 1998, 54 (34) :9981-9994

[2] PREPARATION OF ENANTIOMERICALLY PURE PROTECTED 4-OXO-ALPHA-AMINO ACIDS AND 3-ARYL-ALPHA-AMINO ACIDS FROM SERINE [J].

JACKSON, RFW ;

WISHART, N ;

WOOD, A ;

JAMES, K ;

WYTHES, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (12) :3397-3404

[3] Structure-based design of a novel series of nonpeptide ligands that bind to the pp60src SH2 domain [J].

Lunney, EA ;

Para, KS ;

Rubin, JR ;

Humblet, C ;

Fergus, JH ;

Marks, JS ;

Sawyer, TK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (51) :12471-12476

[4] A fluorescence polarization based Src-SH2 binding assay [J].

Lynch, BA ;

Loiacono, KA ;

Tiong, CL ;

Adams, SE ;

MacNeil, IA .

ANALYTICAL BIOCHEMISTRY, 1997, 247 (01) :77-82

[5]

SAWYER TK, 1998, PEPTIDE SCI, V47, P248

[6] Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice [J].

Schwartzberg, PL ;

Xing, LP ;

Hoffmann, O ;

Lowell, CA ;

Garrett, L ;

Boyce, BF ;

Varmus, HE .

GENES & DEVELOPMENT, 1997, 11 (21) :2835-2844

[7] TARGETED DISRUPTION OF THE C-SRC PROTOONCOGENE LEADS TO OSTEOPETROSIS IN MICE [J].

SORIANO, P ;

MONTGOMERY, C ;

GESKE, R ;

BRADLEY, A .

CELL, 1991, 64 (04) :693-702

← 1 →