Conserved pathways within bacteria and yeast as revealed by global protein network alignment

被引：349

作者：

Kelley, BP

Sharan, R

Karp, RM

Sittler, T

Root, DE

Stockwell, BR

Ideker, T

机构：

[1] Whitehead Inst Biomed Res, Cambridge Ctr 9, Cambridge, MA 02142 USA

[2] Int Comp Sci Inst, Berkeley, CA 94704 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 20期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1073/pnas.1534710100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We implement a strategy for aligning two protein-protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and complexes. Using this approach we show that the protein-protein interaction networks of two distantly related species, Saccharomyces cerevisiae and Helicobacter pylori, harbor a large complement of evolutionarily conserved pathways, and that a large number of pathways appears to have duplicated and specialized within yeast. Analysis of these findings reveals many well characterized interaction pathways as well as many unanticipated pathways, the significance of which is reinforced by their presence in the networks of both species.

引用

页码：11394 / 11399

页数：6

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