Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity

被引：24
|
作者：
Kraevaya, Olga A. [1 ,2 ]
Peregudov, Alexander S. [3 ]
Godovikov, Ivan A. [3 ]
Shchurik, Elena, V [2 ]
Martynenko, Vyacheslav M. [2 ]
Shestakov, Alexander F. [2 ,4 ]
Balzarini, Jan [4 ,5 ]
Schols, Dominique [5 ]
Troshin, Pavel A. [1 ,2 ]
机构：
[1] Skolkovo Inst Sci & Technol, Nobel St 3, Moscow 143026, Russia
[2] IPCP RAS, Semenov Prospect 1, Chernogolovka 141432, Russia
[3] INEOS RAS, Vavylova St 28,B-334, Moscow 119991, Russia
[4] Moscow Lomonosov State Univ, Fac Fundamental Phys & Chem Engn, GSP 1,1-51 Leninskie Gag, Moscow 119991, Russia
[5] Katholieke Univ Leuven, Rega Inst Med Res, Herestr 49, B-3000 Leuven, Belgium
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 08期
基金：
俄罗斯科学基金会;
关键词：
CHLOROFULLERENE C60CL6; C-60; POLYMERIZATION; VIRUS;
D O I：
10.1039/c9cc08400b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report unprecedented Friedel-Crafts arylation of chlorofullerenes C60Cl6 and C70Cl8 with unprotected carboxylic acids as an efficient single-step synthesis of the inherently stable water-soluble fullerene derivatives. Using this method, a series of previously unaccessible compounds was obtained without chromatographic purification in almost quantitative yields. Promising anti-HIV activity comparable to characteristics of commercial drugs was demonstrated for some of these compounds.
引用
收藏
页码：1179 / 1182
页数：4
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