Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling

被引：32
作者：
Gao, Jian [1 ,2 ]
Zhang, Xiaodong [3 ,4 ]
Jiang, Lei [5 ]
Li, Yan [6 ]
Zheng, Qianqian [1 ]
机构：
[1] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang 110122, Peoples R China
[2] China Med Univ, Sci Expt Ctr, Shenyang 110122, Peoples R China
[3] Capital Med Univ, Dept Gen Surg, Beijing Friendship Hosp, Beijing 100000, Peoples R China
[4] Natl Clin Res Ctr Digest Dis, Beijing 100000, Peoples R China
[5] Jinzhou Med Univ, Dept Gen Surg, Affiliated Hosp, Jinzhou 121000, Peoples R China
[6] Jinzhou Med Univ, Dept Radiotherapy, Affiliated Hosp 1, Jinzhou 121000, Peoples R China
来源：
CELL COMMUNICATION AND SIGNALING | 2022年 / 20卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Extracellular vesicles; Tumor microenvironment; Angiogenesis; Remodeling; Targeted therapy; DRUG-DELIVERY VEHICLES; PROGENITOR CELLS; PROMOTES ANGIOGENESIS; EXOSOMES; MICROPARTICLES; RNA; ACTIVATION; SECRETION; APOPTOSIS; INVASION;
D O I：
10.1186/s12964-022-00904-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cancer progression involves several biological steps where angiogenesis is a key tumorigenic phenomenon. Extracellular vesicles (EVs) derived from tumor cells and other cells in the tumor microenvironment (TME) help modulate and maintain favorable microenvironments for tumors. Endothelial cells (ECs) activated by cancer-derived EVs have important roles in tumor angiogenesis. Interestingly, EVs from ECs activate tumor cells, i.e. extracellular matrix (ECM) remodeling and provide more supplements for tumor cells. Thus, EV communications between cancer cells and ECs may be effective therapeutic targets for controlling cancer progression. In this review, we describe the current knowledge on EVs derived from ECs and we examine how these EVs affect TME remodeling.
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页数：10
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