Self-assembly of amphiphilic ABA random triblock copolymers in water

被引：7
|
作者：
Kozawa, Susan K. [1 ,2 ]
Matsumoto, Kazuma [1 ]
Suzuki, Ayaka [1 ]
Sawamoto, Mitsuo [1 ,3 ]
Terashima, Takaya [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan
[2] Case Western Reserve Univ, Dept Macromol Sci & Engn, 2100 Adelbert Rd, Cleveland, OH 44106 USA
[3] Chubu Univ, Inst Sci & Technol Res, 1200 Matsumoto Cho, Kasugai, Aichi 4878501, Japan
来源：
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2019年 / 57卷 / 03期
关键词：
amphiphilic random copolymer; block copolymer; micelle; self-assembly; thermoresponsive; DRUG-DELIVERY; POLYMERIC MICELLES; BLOCK-COPOLYMERS; SYSTEMS; TECHNOLOGIES;
D O I：
10.1002/pola.29178
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Self-assembly of amphiphilic ABA random triblock copolymers in water serves as a novel approach to create unique structure micelles connected with flexible linkages. The ABA triblock copolymers consist of amphiphilic random copolymers bearing hydrophilic poly(ethylene glycol) and hydrophobic dodecyl pendants as the A segments and a hydrophilic poly(ethylene oxide) (PEO) as the middle B segment. The A block is varied in dodecyl methacrylate content of 20%-50% and degree of polymerization (DP) of 100-200. By controlling the composition and DP of the A block, various architectures can be tailor-made as micelles in water: PEO-linked double core unimer micelles, PEO-looped unimer or dimer micelles, and multichain micelles. Those PEO-linked or looped micelles further exhibit thermoresponsive solubility in water. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 313-321
引用
收藏
页码：313 / 321
页数：9
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