Preparation of Indomethacin Solid Dispersions by Mechanochemical Technology and the Characterization

被引：0
作者：
Xiao, Yin [1 ]
Yu, Meijing [2 ]
Jin, Tingyu [1 ]
Zhu, Xingyi [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2021年 / 40卷 / 09期
关键词：
ball milling; dissolution rate; indomethacin; solid dispersions; solubility; SOLUBILITY; RELEASE; DRUG;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Solid dispersions (SDs) of indomethacin (IMC) with different excipients were prepared by mechanical ball milling to improve the solubility and dissolution rate of IMC. The SDs of IMC was characterized by differential scanning calorimetry, X-ray diffraction, fourier transform infrared spectroscopy. In addition, the solubility, dissolution rate and stability tests were also carried out to evaluate the SDs of IMC. The results showed that IMC was in an amorphous state and uniformly dispersed in SD. Meanwhile, the solubility and dissolution rate of IMC in SDs were significantly improved and hydroxypropyl methylcellulose acetate succinate was selected as optimal excipients to prepare SDs of IMC.
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页码：2236 / 2243
页数：8
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