Bile acid-oligodeoxynucleotide conjugates: Synthesis and liver excretion in rats

被引：15
|
作者：
Starke, D
Lischka, K
Pagels, P
Uhlmann, E
Kramer, W
Wess, G
Petzinger, E
机构：
[1] Univ Giessen, Inst Pharmacol & Toxicol, D-35392 Giessen, Germany
[2] Aventis Pharma Deutschland GMBH, D-65926 Frankfurt, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 07期
关键词：
D O I：
10.1016/S0960-894X(01)00048-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of bile acid-oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid-oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：945 / 949
页数：5
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