Cascade catalysis - strategies and challenges en route to preparative synthetic biology

被引：271

作者：

Muschiol, Jan ^{[1
]}

Peters, Christin ^{[1
]}

Oberleitner, Nikolin ^{[2
]}

Mihovilovic, Marko D. ^{[2
]}

Bornscheuer, Uwe T. ^{[1
]}

Rudroff, Florian ^{[2
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Inst Biochem, Dept Biotechnol & Enzyme Catalysis, D-17489 Greifswald, Germany

[2] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 27期

基金：

奥地利科学基金会;

关键词：

CONTINUOUS-FLOW HYDROGENATION; COMPUTER-AIDED-DESIGN; ONE-POT; ESCHERICHIA-COLI; ENZYMATIC CONVERSION; IMMOBILIZED ENZYMES; (S)-MANDELIC ACID; ORGANIC-SYNTHESIS; PATHWAY DESIGN; FERULIC ACID;

D O I：

10.1039/c4cc08752f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nature's smartness and efficient assembling cascade type reactions inspired biologists and chemists all around the world. Tremendous effort has been directed towards the understanding and mimicking of such networks. In recent years considerable progress has been made in developing multistep one-pot reactions combining either advantage of chemo-, regio-, and stereoselectivity of biocatalysts or promiscuity and productivity of chemocatalysts. In this context several concepts, inspired by different disciplines (biocatalysis, metabolic engineering, synthetic chemistry, and material science), have been evolved. This review will focus on major contributions in the field of cascade reactions over the last three years.

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收藏

页码：5798 / 5811

页数：14

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