Motor unit number index (MUNIX) versus motor unit number estimation (MUNE): A direct comparison in a longitudinal study of ALS patients

被引:74
作者
Boekestein, Werner A. [1 ,2 ,3 ]
Schelhaas, Helenius J. [1 ]
van Putten, Michel J. A. M. [2 ,3 ]
Stegeman, Dick F. [1 ,4 ]
Zwarts, Machiel J. [5 ]
van Dijk, Johannes P. [1 ,6 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Neurol, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands
[2] Univ Twente, Med Spectrum Twente, Dept Neurol & Clin Neurophysiol, Enschede, Netherlands
[3] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Enschede, Netherlands
[4] Vrije Univ Amsterdam, Fac Human Movement Sci, Res Inst MOVE, Amsterdam, Netherlands
[5] Epilepsy Ctr Kempenhaeghe, Heeze, Netherlands
[6] Univ Ulm Klinikum, Klin Kieferorthopadie & Orthodontie, Ulm, Germany
关键词
ALS; MUNIX; MUNE; Monitoring disease progression; HD-surface EMG; AMYOTROPHIC-LATERAL-SCLEROSIS; DISEASE PROGRESSION; ELECTRODE; SURFACE; SIZE;
D O I
10.1016/j.clinph.2012.01.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To evaluate how the motor unit number index (MUNIX) is related to high-density motor unit number estimation (HD-MUNE) in healthy controls and patients with amyotrophic lateral sclerosis (ALS). Methods: Both MUNIX and HD-MUNE were performed on the thenar muscles in 18 ALS patients and 24 healthy controls. Patients were measured at baseline, within 2 weeks, and after 4 and 8 months. Clinical evaluation included Medical Research Council (MRC) scale and the ALS functional rating scale (ALSFRS). Results: There was a significant positive correlation between MUNE and MUNIX values in ALS patients (r = 0.49 at baseline; r = 0.56 at 4 months; r = 0.56 at 8 months, all p < 0.05), but not in healthy controls. After 8 months, both MUNE and MUNIX values of the ALS patients decreased significantly more compared to MRC scale, ALS functional rating scale (ALSFRS) and compound muscle action potential (CMAP) (p < 0.05). There was no significant difference in relative decline of MUNIX and HD-MUNE values. Conclusions: In ALS patients, MUNIX and HD-MUNE are significantly correlated. MUNIX has an almost equivalent potential in detecting motor neuron loss compared to HD-MUNE. Significance: MUNIX could serve as a reliable and sensitive marker for monitoring disease progression in ALS. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1644 / 1649
页数:6
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