Noscapine, a tubulin binding anticancer agent undergoing Phase I/II clinical trials, inhibits tumor growth in nude mice bearing human xenografts of breast, lung, ovarian, brain, and prostrate origin. The analogues of noscapine like 9-bromonoscapine (EM011) are 5 to 10-fold more active than parent compound, noscapine. Noscapinoids inhibit the proliferation of cancer cells that are resistant to paclitaxel and epothilone. Noscapine also potentiated the anticancer activity of doxorubicin in a synergistic manner against triple negative breast cancer (TNBC). However, physicochemical and pharmacokinetic (ED50 similar to 300-600 mg/kg bodyweight) limitations of noscapine present hurdle in development of commercial anticancer formulations. Therefore, objectives of the present review are to summarize the chemotherapeutic potential of noscapine and implications of nanoscale based drug delivery systems in enhancing the therapeutic efficacy of noscapine in cancer cells. We have constructed noscapine-enveloped gelatin nanoparticles, NPs and poly (ethylene glycol) grafted gelatin NPs as well as inclusion complex of noscapine in beta-cyclodextrin (beta-CD) and evaluated their physicochemical characteristics. The Fe3O4 NPs were also used to incorporate noscapine in its polymeric nanomatrix system where molecular weight of the polymer governed the encapsulation efficiency of drug. The enhanced noscapine delivery using PAR-targeted optical-MR imaging trackable NPs offer a great potential for image directed targeted delivery of noscapine. Human Serum Albumin NPs (150-300 nm) as efficient noscapine drug delivery systems have also been developed for potential use in breast cancer.
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Dept Biol, Tuskegee, AL 36088 USA
Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Abdalla, Mohamed O.
;
Karna, Prasanthi
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机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Karna, Prasanthi
;
Sajja, Hari Krishna
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Sajja, Hari Krishna
;
Mao, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Mao, Hui
;
Yates, Clayton
论文数: 0引用数: 0
h-index: 0
机构:
Dept Biol, Tuskegee, AL 36088 USA
Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Yates, Clayton
;
Turner, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Dept Biol, Tuskegee, AL 36088 USA
Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Abdalla, Mohamed O.
;
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Aneja, Ritu
;
Dean, Derrick
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama, Dept Mat Sci & Engn, Birmingham, AL 35294 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Dean, Derrick
;
Rangari, Vijay
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Tuskegee Ctr Adv Mat, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Rangari, Vijay
;
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Russell, Albert
;
Jaynes, Jessie
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, George Washington Carver Agr Expt Stn, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Jaynes, Jessie
;
Yates, Clayton
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Yates, Clayton
;
Turner, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
机构:
Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, Kanazawa, Ishikawa 9201192, JapanGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Miyagi, Tohru
;
Karna, Prasanthi
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Karna, Prasanthi
;
Ezell, Tucker
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Ezell, Tucker
;
Shukla, Deep
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Shukla, Deep
;
Gupta, Meenakshi Vij
论文数: 0引用数: 0
h-index: 0
机构:
W Georgia Hosp, La Grange, GA 30240 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Gupta, Meenakshi Vij
;
Yates, Clayton
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Yates, Clayton
;
Chinni, Sreenivasa R.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Dept Urol, Sch Med, Detroit, MI 48201 USA
Wayne State Univ, Dept Pathol, Sch Med, Detroit, MI 48201 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Chinni, Sreenivasa R.
;
Zhau, Haiyen
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Zhau, Haiyen
;
Chung, Leland W. K.
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Chung, Leland W. K.
;
Joshi, Harish C.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Dept Cell Biol, Sch Med, Atlanta, GA 30322 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Dept Biol, Tuskegee, AL 36088 USA
Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Abdalla, Mohamed O.
;
Karna, Prasanthi
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Karna, Prasanthi
;
Sajja, Hari Krishna
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Sajja, Hari Krishna
;
Mao, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Mao, Hui
;
Yates, Clayton
论文数: 0引用数: 0
h-index: 0
机构:
Dept Biol, Tuskegee, AL 36088 USA
Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Yates, Clayton
;
Turner, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Dept Biol, Tuskegee, AL 36088 USA
Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Abdalla, Mohamed O.
;
论文数: 引用数:
h-index:
机构:
Aneja, Ritu
;
Dean, Derrick
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama, Dept Mat Sci & Engn, Birmingham, AL 35294 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Dean, Derrick
;
Rangari, Vijay
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Tuskegee Ctr Adv Mat, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Rangari, Vijay
;
论文数: 引用数:
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机构:
Russell, Albert
;
Jaynes, Jessie
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, George Washington Carver Agr Expt Stn, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Jaynes, Jessie
;
Yates, Clayton
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Yates, Clayton
;
Turner, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USATuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
机构:
Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, Kanazawa, Ishikawa 9201192, JapanGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Miyagi, Tohru
;
Karna, Prasanthi
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Karna, Prasanthi
;
Ezell, Tucker
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Ezell, Tucker
;
Shukla, Deep
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Biol, Atlanta, GA 30303 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Shukla, Deep
;
Gupta, Meenakshi Vij
论文数: 0引用数: 0
h-index: 0
机构:
W Georgia Hosp, La Grange, GA 30240 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Gupta, Meenakshi Vij
;
Yates, Clayton
论文数: 0引用数: 0
h-index: 0
机构:
Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA
Tuskegee Univ, Ctr Canc Res, Tuskegee, AL 36088 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Yates, Clayton
;
Chinni, Sreenivasa R.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Dept Urol, Sch Med, Detroit, MI 48201 USA
Wayne State Univ, Dept Pathol, Sch Med, Detroit, MI 48201 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Chinni, Sreenivasa R.
;
Zhau, Haiyen
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Zhau, Haiyen
;
Chung, Leland W. K.
论文数: 0引用数: 0
h-index: 0
机构:
Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA
Chung, Leland W. K.
;
Joshi, Harish C.
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Dept Cell Biol, Sch Med, Atlanta, GA 30322 USAGeorgia State Univ, Dept Biol, Atlanta, GA 30303 USA