Planarian stem cell niche, the challenge for understanding tissue regeneration

被引：18

作者：

Rossi, Leonardo ^{[1
]}

Salvetti, Alessandra ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, Unit Expt Biol & Genet, Via Volta 4, Pisa, Italy

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2019年 / 87卷

关键词：

Stem cells; Niche; Neoblasts; Planarians; DOPAMINERGIC NEURAL-NETWORK; CENTRAL-NERVOUS-SYSTEM; NEOBLAST REPOPULATION; POLARITY; GENE; DIFFERENTIATION; PROLIFERATION; HEAD; IDENTIFICATION; MAINTENANCE;

D O I：

10.1016/j.semcdb.2018.03.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cell fate depends on surrounding microenvironment, the so called niche. For this reason, understanding stem cell niche is one of the most challenging target in cell biology field and need to be unraveled with in vivo studies. Planarians offer this unique opportunity, as their stem cells, the neoblasts, are abundant, highly characterized and genetically modifiable by RNA interference in alive animals. However, despite impressive advances have been done in the understanding planarian stem cells and regeneration, only a few information is available in defining signals from differentiated tissues, which affect neoblast stemness and fate. Here, we review on molecular factors that have been found activated in differentiated tissues and directly or indirectly affect neoblast behavior, and we suggest future directions for unravelling this challenge in understanding planarian stem cells. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：30 / 36

页数：7

共 99 条

[1] Smed-Evi/Wntless is required for β-catenin-dependent and -independent processes during planarian regeneration [J].