Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor

被引:49
作者
Moehle, Mark S. [1 ,2 ]
Pancani, Tristano [1 ,2 ]
Byun, Nellie [1 ,2 ,3 ]
Yohn, Samantha E. [1 ,2 ]
Wilson, George H., III [1 ,2 ,3 ]
Dickerson, Johnathan W. [1 ,2 ]
Remke, Daniel H. [1 ,2 ]
Xiang, Zixiu [1 ,2 ]
Niswender, Colleen M. [1 ,2 ,4 ]
Wess, Jurgen [5 ]
Jones, Carrie K. [1 ,2 ]
Lindsley, Craig W. [1 ,2 ]
Rook, Jerri M. [1 ,2 ]
Conn, P. Jeffrey [1 ,2 ,4 ]
机构
[1] Vanderbilt Univ, Vanderbilt Ctr Neurosci Drug Discovery, 221 Kirkland Hall, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37235 USA
[3] Vanderbilt Univ, Inst Imaging Sci, 221 Kirkland Hall, Nashville, TN 37235 USA
[4] Vanderbilt Univ, Sch Med, Vanderbilt Kennedy Ctr, Nashville, TN 37212 USA
[5] NIDDK, Mol Signaling Sect, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA
关键词
ACETYLCHOLINE-RECEPTORS; ALLOSTERIC MODULATORS; D1; RECEPTOR; RAT; STRIATUM; NUCLEUS; INTERNEURONS; SUBTYPE; NEURONS; STIMULATION;
D O I
10.1016/j.neuron.2017.12.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cholinergic regulation of dopaminergic inputs into the striatum is critical for normal basal ganglia (BG) function. This regulation of BG function is thought to be primarily mediated by acetylcholine released from cholinergic interneurons (Chls) acting locally in the striatum. We now report a combination of pharmacological, electrophysiological, optogenetic, chemogenetic, and functional magnetic resonance imaging studies suggesting extra-striatal cholinergic projections from the pedunculopontine nucleus to the substantia nigra pars reticulata (SNr) act on muscarinic acetylcholine receptor subtype 4 (M-4) to oppose cAMP-dependent dopamine receptor subtype 1 (D-1) signaling in presynaptic terminals of direct pathway striatal spiny projections neurons. This induces a tonic inhibition of transmission at direct pathway synapses and D-1-mediated activation of motor activity. These studies provide important new insights into the unique role of M-4 in regulating BG function and challenge the prevailing hypothesis of the centrality of striatal ChIs in opposing dopamine regulation of BG output.
引用
收藏
页码:1358 / +
页数:19
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