mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

被引：405

作者：

Weichhart, Thomas ^{[1
]}

机构：

[1] Med Univ Vienna, Inst Med Genet, Ctr Pathobiochem & Genet, Vienna, Austria

来源：

GERONTOLOGY | 2018年 / 64卷 / 02期

基金：

奥地利科学基金会;

关键词：

Rapamycin; Calorie restriction; Metabolic reprogramming; STEM-CELLS; AMINO-ACID; RAPAMYCIN; TOR; DROSOPHILA; GROWTH; TRANSLATION; METABOLISM; MECHANISMS; EXTENSION;

D O I：

10.1159/000484629

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling hub that senses and integrates environmental and intracellular nutrient and growth factor signals to coordinate basic cellular and organismal responses such as cell growth, proliferation, apoptosis, and inflammation depending on the individual cell and tissue. A growing list of evidence suggests that mTOR signaling influences longevity and aging. Inhibition of the mTOR complex 1 (mTORC1) with rapamycin is currently the only known pharmacological treatment that increases lifespan in all model organisms studied. This review discusses the potential mechanisms how mTOR signaling controls lifespan and influences aging-related processes such as cellular senescence, metabolism, and stem cell function. Understanding these processes might provide novel therapeutic approaches to influence longevity and aging-related diseases. (c) 2017 S. Karger AG, Basel

引用

页码：127 / 134

页数：8

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