Eosinophils in COPD: just another biomarker?

被引：164

作者：

Bafadhel, Mona ^{[1
]}

Pavord, Ian D. ^{[1
]}

Russell, Richard E. K. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Resp Med Unit, Oxford OX3 7FZ, England

来源：

LANCET RESPIRATORY MEDICINE | 2017年 / 5卷 / 09期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; INHALED FLUTICASONE FUROATE; INNATE LYMPHOID-CELLS; BLOOD EOSINOPHILS; DOUBLE-BLIND; GENERAL-POPULATION; INDUCED SPUTUM; CATIONIC PROTEIN; EXTRAFINE BECLOMETHASONE/FORMOTEROL; SALMETEROL-FLUTICASONE;

D O I：

10.1016/S2213-2600(17)30217-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Eosinophils are innate immune cells that, under certain conditions, can be recruited to the lungs, where they have an incompletely understood role in health and disease. Eosinophils have been found in the airways, tissues, and circulation of patients with COPD, during both stable disease and exacerbations. Epidemiological studies and post-hoc analyses of clinical trials of corticosteroid treatment for COPD have shown that the blood eosinophil count is associated with the risk of COPD exacerbations, mortality, decline in FEV1, and response to both inhaled and systemic corticosteroids. Further studies are urgently needed to explore the contribution of eosinophils to the mechanism of disease in COPD and to identify their association with levels of clinical risk. In this review, we explore the role of the eosinophil as a biomarker and mediator of disease in COPD.

引用

页码：747 / 759

页数：13

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