An overview of the MAGE gene family with the identification of all human members of the family

被引:6
|
作者
Chomez, P
De Backer, O
Bertrand, M
De Plaen, E
Boon, T
Lucas, S
机构
[1] Ludwig Inst Canc Res, Brussels Branch, B-1200 Brussels, Belgium
[2] Univ Catholique Louvain, Cellular Genet Unit, B-1200 Brussels, Belgium
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The first human members of the MAGE gene family that have been described are expressed in tumor cells but silent in normal adult tissues except in the male germ line. Hence, they encode strictly tumor-specific antigens that represent attractive targets for cancer immunotherapy, However, other members of the family were recently found to be expressed in normal cells, indicating that the family is larger and more disparate than initially expected. We therefore performed a database screening to identify all of the recorded members of both classes of human MAGE genes. This report provides an overview of the MAGE family and proposes a general nomenclature for all of the MAGE genes identified thus far. We found that the MAGE-D genes were particularly well conserved between man and mouse, suggesting that they exert important functions. In addition, the genomic structure of the MACE-D genes indicates that one of them corresponds to the founder member of the family, and that all of the other MAGE genes are retrogenes derived from that common ancestral gene. Intriguingly, the COOH-terminal domain of MAGE-D3 was found to be identical to trophinin, a previously described protein believed to be involved in embryo implantation.
引用
收藏
页码:5544 / 5551
页数:8
相关论文
共 50 条
  • [1] Identification of a new, unorthodox member of the MAGE gene family
    Pold, M
    Zhou, J
    Chen, GL
    Hall, JM
    Vescio, RA
    Berenson, JR
    GENOMICS, 1999, 59 (02) : 161 - 167
  • [2] Identification and characterization of three members of the human metallocarboxypeptidase gene family
    Wei, SW
    Segura, S
    Vendrell, J
    Aviles, FX
    Lanoue, E
    Day, R
    Feng, Y
    Fricker, LD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (17) : 14954 - 14964
  • [3] The 'RM family' - Identification of all of its members
    Emons H.
    Accreditation and Quality Assurance, 2006, 10 (12) : 690 - 691
  • [4] Expression of the MAGE gene family in human hepatocellular carcinoma
    Tahara, K
    Mori, M
    Sadanaga, N
    Sakamoto, Y
    Kitano, S
    Makuuchi, M
    CANCER, 1999, 85 (06) : 1234 - 1240
  • [5] Expression of the MAGE gene family in human gastric carcinoma
    Li, J
    Yang, Y
    Fujie, T
    Tanaka, F
    Mimori, K
    Haraguchi, M
    Ueo, H
    Mori, M
    Akiyoshi, T
    ANTICANCER RESEARCH, 1997, 17 (5A) : 3559 - 3563
  • [6] EXPRESSION OF THE MAGE GENE FAMILY IN HUMAN LYMPHOCYTIC-LEUKEMIA
    SHICHIJO, S
    TSUNOSUE, R
    MASUOKA, K
    NATORI, H
    TAMAI, M
    MIYAJIMA, J
    SAGAWA, K
    ITOH, K
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 1995, 41 (02) : 95 - 103
  • [7] Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family
    Tanzarella, S
    Russo, V
    Lionello, I
    Dalerba, P
    Rigatti, D
    Bordignon, C
    Traversari, C
    CANCER RESEARCH, 1999, 59 (11) : 2668 - 2674
  • [8] CLONING OF THE MEMBERS OF THE HUMAN CYSTATIN GENE FAMILY
    SAITOH, E
    ISEMURA, S
    SANADA, K
    JOURNAL OF DENTAL RESEARCH, 1990, 69 : 167 - 167
  • [9] Identification of two new members of the CSMD gene family
    Lau, WL
    Scholnick, SB
    GENOMICS, 2003, 82 (03) : 412 - 415